Subretinal fibrosis and uveitis syndrome associated with ulcerative colitis

• Published in: International journal of colorectal disease Vol. 22; no. 3; pp. 333 - 334
• Main Authors: FUENTES-PAEZ, Graciana, MARTINEZ-OSORIO, Hernan, HERRERAS, José M, CALONGE, Margarita
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.03.2007; Berlin Springer Nature B.V
• Subjects: Adult; Biological and medical sciences; Colitis, Ulcerative - complications; Female; Fibrosis; Gastroenterology. Liver. Pancreas. Abdomen; Glucocorticoids - administration & dosage; Humans; Immunosuppressive Agents - administration & dosage; Medical sciences; Ophthalmology; Other diseases. Semiology; Retinal Diseases - drug therapy; Retinal Diseases - etiology; Retinal Diseases - pathology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Uvea diseases; Uveitis - drug therapy; Uveitis - etiology; Choroiditis; Crohn disease; Eye disease; Multifocal fibrosclerosis; Inflammatory bowel disease, Multifocal choroiditis, Subretinal fibrosis and panuveitis syndrome; Fibrosis; Uveitis; Digestive diseases; Intestinal disease; Uvea disease; Inflammatory disease; Ulcerative colitis
• ISSN: 0179-1958; 1432-1262
• DOI: 10.1007/s00384-006-0137-2

We report a case of subretinal fibrosis and panuveitis syndrome as an extraintestinal manifestation of ulcerative colitis. We present an interventional case report of a 40-year-old female patient with inactive ulcerative colitis referred to our center for refractory uveitis in her right eye. She was diagnosed with subretinal fibrosis and uveitis syndrome after work-up ruled out tuberculosis, bartonellosis, Lyme disease, and sarcoidosis. Right eye multifocal choroiditis and panuveitis syndrome with subretinal fibrosis was diagnosed, and posterior pole subretinal fibrosis caused a 90% loss of visual efficiency. She had concurrent dermatological manifestations but no gastrointestinal symptoms. One year of immunosuppressive therapy with methotrexate (7.5 mg/week) controlled ocular inflammation. Two colitis episodes, with no visual involvement, were recorded during follow-up. Her final, right-eye, best-corrected visual acuity remained stable at 0.160 due to scarring sequela after 7 years of follow-up. Subretinal fibrosis and uveitis syndrome can occur as a sight-threatening extraintestinal manifestation of ulcerative colitis.