Cobalt-catalysed C-H carbonylative cyclisation of aliphatic amides

A cobalt-catalysed C-H carbonylation of aliphatic carboxamide derivatives is described, employing commercially available Co(II)-salts in the presence of a silver oxidant. This operationally simple process utilises an atmospheric pressure of CO and generates a range of substituted succinimide product...

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Bibliographic Details
Published inChemical science (Cambridge) Vol. 8; no. 4; pp. 2588 - 2591
Main Authors Williamson, Patrick, Galvan, Alicia, Gaunt, Matthew J.
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.04.2017
Subjects
Aliphatic compounds
Amides
Atmospheric pressure
Barometric pressure
Bearing
Carbonyls
Chemistry
Chemistry, Multidisciplinary
Derivatives
Physical Sciences
Science & Technology
Succinimides
OXIDATIVE CARBONYLATION
DIRECTING GROUP
FUNCTIONALIZATION
UNACTIVATED C(SP)-H BONDS
ACTIVATION
TOLUENE DERIVATIVES
ARENES
ARYLATION
C(SP)-H
ALKYNES
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Summary:A cobalt-catalysed C-H carbonylation of aliphatic carboxamide derivatives is described, employing commercially available Co(II)-salts in the presence of a silver oxidant. This operationally simple process utilises an atmospheric pressure of CO and generates a range of substituted succinimide products bearing diverse functional groups that can be successfully accessed via this methodology.
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content type line 23
ISSN:2041-6520
2041-6539
DOI:10.1039/c6sc05581h