Hepatocellular necrosis during frog virus 3-induced hepatitis of mice: An electron microscopic study

The toxic degenerative hepatitis induced by Frog Virus 3 in mice is characterized by late cytoplasmic alterations of the hepatocytes as well as early nuclear lesions. These alterations vary according to the dose of virus used. The inoculation of one lethal dose is followed by an alteration of both r...

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Bibliographic Details
Published inExperimental and molecular pathology Vol. 27; no. 1; pp. 68 - 80
Main Authors Bingen, Annick, Kirn, André
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.08.1977
Subjects
Animals
Anura
Cell Nucleus - ultrastructure
Cytoplasm - ultrastructure
DNA Viruses
Endoplasmic Reticulum - ultrastructure
Hepatitis, Viral, Animal - pathology
Lipid Metabolism
Liver - pathology
Liver Glycogen - metabolism
Mice
Mitochondria, Liver - ultrastructure
Necrosis
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Summary:The toxic degenerative hepatitis induced by Frog Virus 3 in mice is characterized by late cytoplasmic alterations of the hepatocytes as well as early nuclear lesions. These alterations vary according to the dose of virus used. The inoculation of one lethal dose is followed by an alteration of both rough and smooth endoplasmic reticula (appearance of fingerprints and hypertrophy of SER), an accumulation of lipids, and a final necrosis. With high doses of virus (20 LD) lesions of a much more drastic nature can be shown: The RER disrupts and even disappears. Mitochondrial alterations can be seen just before the death of the animals, whereas steatosis and SER hypertrophy have never been observed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0014-4800
1096-0945
DOI:10.1016/0014-4800(77)90020-X