Short communication high risk of endothelial dysfunction in HIV individuals may result from deregulation of circulating endothelial cells and endothelial progenitor cells

Endothelial progenitor cells (EPC) and circulating endothelial cells (CEC) have recently been considered as biomarkers of cardiovascular risk (CVDR) in healthy subjects. The impact of HIV infection on these cells is not well known. A case-control study was conducted in 15 antiretroviral-naive HIV(+)...

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Published inAIDS research and human retroviruses Vol. 28; no. 7; p. 656
Main Authors López, Mariola, Vispo, Eugenia, San Román, Jesús, Herrero, Dolores, Peris, Alejandra, Corral, Angelica, Soriano, Vicente, Benito, Jose Miguel
Format Journal Article
LanguageEnglish
Published United States 01.07.2012
Subjects
Adult
Atherosclerosis - etiology
Atherosclerosis - immunology
Atherosclerosis - physiopathology
Case-Control Studies
Endothelial Cells - pathology
Endothelium, Vascular - immunology
Endothelium, Vascular - physiopathology
Female
HIV Seronegativity
HIV Seropositivity - complications
HIV Seropositivity - immunology
HIV Seropositivity - physiopathology
Humans
Male
Risk Factors
Smoking - immunology
Stem Cells - pathology
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Summary:Endothelial progenitor cells (EPC) and circulating endothelial cells (CEC) have recently been considered as biomarkers of cardiovascular risk (CVDR) in healthy subjects. The impact of HIV infection on these cells is not well known. A case-control study was conducted in 15 antiretroviral-naive HIV(+) patients and 15 HIV-negative controls. The quantitative profile of CEC and EPC differed significantly in HIV(+) and HIV(-) subjects. HIV(+) subjects had significantly more CEC and less EPC than HIV(-) controls. A quantitative impairment in the balance of the CEC and EPC might contribute to the increased subclinical CVDR in HIV(+) patients.
ISSN:1931-8405
DOI:10.1089/aid.2011.0152