Glucose homeostasis in thyroxine-treated BHE/cdb rats fed corn oil or hydrogenated coconut oil

• Published in: The Journal of nutritional biochemistry Vol. 4; no. 1; pp. 20 - 26
• Main Authors: Kim, Moon-Jeong Chang, Pan, Ju Shin, Berdanier, Carolyn D.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 1993; Elsevier Science
• Subjects: aceite de coco; aceite de maiz; BHE/cdb rats; Biological and medical sciences; coconut oil; Cori cycle; corps gras; diet; dieta; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; fats; glucosa; glucose; glucose turnover; graisse hydrogenee; grasa hidrogenada; grasas; huile de coco; huile de mais; hydrogenated coconut oil; hydrogenated fats; injection; inyeccion; lipogenesis; maize oil; Medical sciences; rat; rata; rats; regime alimentaire; thyroxine; tiroxina; hydrogenated coconut oil; thyroxine; lipogenesis; glucose turnover; BHE/cdb rats; Cori cycle; Endocrinopathy; Animal model; Rat; Rodentia; Lipids; Glucose; Non insulin dependent diabetes; Genetic disease; Feeding; Vertebrata; Metabolic disorder; Mammalia; Treatment; Hydrogenated oil; Thyroxine; Turnover; Thyroid hormone; Carbohydrate; Lipogenesis; Impaired glucose tolerance; Gluconeogenesis
• ISSN: 0955-2863; 1873-4847
• DOI: 10.1016/0955-2863(93)90015-O

Glucose turnover was assessed in BHE rats fed either a 6% corn or hydrogenated coconut oil diet and treated with 10 μg thyroxine (T 4/100 g body weight/day or untreated. Regardless of fat souce, measures of fractional irreversible glucose turnover and Cori cycle activity were higher in T 4-treated rats than in control rats. T 4 also increased the alanine to glucose conversion. Treatment with T 4 resulted in less muscle and hepatic glycogen. Lipogenesis was greatly increased in the rats fed hydrogenated coconut oil and this effect was potentiated by T 4 treatment. Blood glucose levels were also lower in this group, suggesting that this blood glucose lowering was due to a combination of treatment effects on glycogenolysis and lipogenesis. It would appear that the main effect of T 4 was to alter the sources of glucose in the total glucose pool in the body, and that the differences in glucose oxidation, synthesis, and recycling were a reflection of the body's adaptation to this reduction.