Fabrication of bioactive 3D printed porous titanium implants with Sr ion-incorporated zeolite coatings for bone ingrowth

Functionalization of porous titanium alloy implants with bioactive coatings to improve bone regeneration performance is hotly pursued in recent decade. Here we demonstrate a facile strategy to design bioactive 3D printed porous titanium implants with strontium (Sr) ion incorporated zeolite coatings...

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Published inJournal of materials chemistry. B, Materials for biology and medicine Vol. 6; no. 20; pp. 3254 - 3261
Main Authors Wang, Shuang, Li, Ruiyan, Li, Dongdong, Zhang, Zhi-Yong, Liu, Guancong, Liang, Haojun, Qin, Yanguo, Yu, Jihong, Li, Yuanyuan
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 28.05.2018
Subjects
Alkaline phosphatase
Apatite
Biocompatibility
Biological activity
Biomedical materials
Body fluids
Bone growth
Bone implants
Coatings
Computer simulation
Corrosion resistance
Crystal growth
Fabrication
Hydrothermal crystal growth
In vitro methods and tests
Ion exchange
Osseointegration
Osteogenesis
Protective coatings
Regeneration
Regeneration (physiology)
Strontium
Surgical implants
Three dimensional models
Three dimensional printing
Titanium
Titanium alloys
Titanium base alloys
Zeolites
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Summary:Functionalization of porous titanium alloy implants with bioactive coatings to improve bone regeneration performance is hotly pursued in recent decade. Here we demonstrate a facile strategy to design bioactive 3D printed porous titanium implants with strontium (Sr) ion incorporated zeolite coatings (SZCs). The SZCs can be uniformly fabricated on the 3D porous scaffolds using an in situ hydrothermal crystal growth method to improve their osteogenesis and osteointegration capacity. In vitro experiments of SZCs on a TC4 disk show that Sr ions can slowly release in the simulated body fluid by means of ion-exchange, thus can drastically improve apatite forming ability, biocompatibility, corrosion resistance, and alkaline phosphatase (ALP) activity. In vivo evaluation on a rabbit model with 3D printed titanium implants shows that the SZCs could significantly induce new bone formation both in and around the porous implants within four weeks. This work may open up a new method for the development of bioactive customized porous implants by functionalization with zeolite coatings for orthopedic applications.
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ISSN:2050-750X
2050-7518
DOI:10.1039/c8tb00328a