Impaired Th1 responses in patients with acute exacerbations of COPD are improved with PD-1 blockade

•Poor T-cell function is implicated in susceptibility to infections in COPD patients.•Proportion of circulating PD-1+ CD4+ T-cells is elevated in AECOPD patients.•Systemic inflammation is associated with elevated proportion of PD-1+ CD4+ T-cells.•PD-1 blockade increased the production of IFNγ, TNF,...

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Published inClinical immunology (Orlando, Fla.) Vol. 188; pp. 64 - 66
Main Authors Tan, Dino B.A., Teo, Teck-Hui, Setiawan, Abdul M., Ong, Nathanael E., Zimmermann, Maja, Hsu, Alan Chen-Yu, Wark, Peter A.B., Moodley, Yuben P.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.2018
Subjects
AECOPD
COPD
PD-1
T-cell
CRP
AECOPD
sTNFR
NTHI
T-cell
sCOPD
CTLA-4
PBMC
PD-1
COPD
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Summary:•Poor T-cell function is implicated in susceptibility to infections in COPD patients.•Proportion of circulating PD-1+ CD4+ T-cells is elevated in AECOPD patients.•Systemic inflammation is associated with elevated proportion of PD-1+ CD4+ T-cells.•PD-1 blockade increased the production of IFNγ, TNF, IL-6 and IL-10 by anti-CD3-induced PBMC.
Bibliography:SourceType-Other Sources-1
ObjectType-Article-2
content type line 63
ObjectType-Correspondence-1
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2017.12.007