Mastocytosis and Anaphylaxis

This article updates current knowledge on epidemiology, risk factors, triggers, and management of anaphylaxis in patients with mastocytosis. Hyperactive mast cells and higher number of effector mast cells are speculated to facilitate anaphylaxis in this condition. In children, increased risk is limi...

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Bibliographic Details
Published inImmunology and allergy clinics of North America Vol. 37; no. 1; p. 153
Main Authors Schuch, Anna, Brockow, Knut
Format Journal Article
LanguageEnglish
Published United States 01.02.2017
Subjects
Adult
Allergens - immunology
Anaphylaxis - immunology
Animals
Arthropod Venoms - immunology
Child
Drug Hypersensitivity - immunology
Humans
Hymenoptera - immunology
Insect Bites and Stings - immunology
Mast Cells - immunology
Mastocytosis - immunology
Risk Factors
Mastocytosis
Anaphylaxis
Mast cell activation syndrome
Drug-induced anaphylaxis
Hymenoptera venom anaphylaxis
Triggers
Risk factors
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Summary:This article updates current knowledge on epidemiology, risk factors, triggers, and management of anaphylaxis in patients with mastocytosis. Hyperactive mast cells and higher number of effector mast cells are speculated to facilitate anaphylaxis in this condition. In children, increased risk is limited to those with extensive skin involvement and high tryptase. In adults, manifestations of anaphylaxis are severe with high frequency of cardiovascular symptoms. Hymenoptera stings are the most common triggers for these reactions; however, idiopathic anaphylaxis and reactions to food or drugs occur. Patients with mastocytosis should be informed about risk of anaphylaxis and prescribing emergency self-medication and installing emergency preparedness before general anesthesia is considered.
ISSN:1557-8607
DOI:10.1016/j.iac.2016.08.017