The Risk Groups for Coronary Heart Disease in Koreans. Assessment by Distribution of Serum Lipid Concentrations

• Published in: Clinical chemistry and laboratory medicine Vol. 37; no. 10; pp. 969 - 974
• Main Authors: Chun, Sail, Min, Won-Ki, Park, Hyosoon, Song, Junghan, Kim, Jin Q, Min, Young Il, Kim, Sung-Ryul, Lee, Seon-Ho
• Format: Journal Article
• Language: English
• Published: Berlin Walter de Gruyter 01.10.1999; New York, NY
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Cardiology. Vascular system; Cholesterol - blood; Coronary Disease - epidemiology; Coronary heart disease; Female; Heart; Humans; Hyperlipidemias - epidemiology; Korea - epidemiology; Male; Medical sciences; Middle Aged; Risk Factors; Triglycerides - blood; Tropical medicine; Asia; Korea; Human; Cholesterolemia; Sex; Cardiovascular disease; Metabolic diseases; Lipids; Coronary heart disease; Epidemiology; Cholesterol; Hypercholesterolemia; Risk factor; Hyperlipemia; Dyslipemia; Age
• ISSN: 1434-6621; 1437-4331
• DOI: 10.1515/CCLM.1999.143

Coronary heart disease is the most severe form of disease caused by atherosclerosis; and there is a strong relationship between serum lipid concentrations and atherosclerosis. By decade of life, means, standard deviations and selected percentiles were calculated according to sex for serum concentrations of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride in 69,563 Koreans. The prevalence of dyslipoproteinemias which were related to high risk of coronary heart disease were assessed. The mean concentrations of serum total cholesterol and LDL-C in the Korean population were 5.02 mmol/l and 3.00 mmol/l. The 75th and 90th percentile concentrations of total cholesterol were 5.59 mmol/l and 6.24 mmol/l. The mean concentrations of serum triglyceride and HDL-C were 1.58 mmol/l and 1.30 mmol/l. The hyperlipoproteinemia type IV (4.8%) was the most frequent, followed by Type IIa (4.6%), hypoalphalipoproteinemia (3.3%), and type IIb (0.2%). According to the National Cholesterol Education Program Adult Treatment Panel II, 4.1% of Korean adults needed the initial drug therapy and 10.8% the initial dietary therapy for hypercholesterolemia. The age and sex-specific treatment guidelines for hypercholesterolemia would make it possible that early intervention could be applied to atherosclerosis in Korean adults.