Immune reactions and nerve repair in mice with sciatic nerve injury 14 days after intraperitoneal injection of Brazil

BALB/c mice were intraperitoneally injected with 10, 5 or 2.5 mg/kg Brazil for 14 days after sciatic nerve injury. Results demonstrate that the spleen T/B lymphocyte stimulation index and serum circulating immune complex concentration were significantly reduced, and the morphology of the soleus musc...

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Published inNeural regeneration research Vol. 7; no. 9; pp. 675 - 679
Main Authors Cao, Jian, Niu, Zhongping, Wang, Yongan, Jiang, Yiwen, Liu, Haoyu, Wang, Binfeng, Yin, Weitian, Li, Lisen
Format Journal Article
LanguageEnglish
Published India Medknow Publications & Media Pvt. Ltd 25.03.2012
Second Department of Orthopedics, Chifeng Municipal Hospital, Chifeng 024000, Inner Mongolia Autonomous Region, China%Department of Hand Surgery, China-Japanese Union Hospital of Jilin University, Changchun 130033, Jilin Province, China
Medknow Publications & Media Pvt Ltd
Subjects
B淋巴细胞
Drug dosages
Immunology
Laboratory animals
Lymphocytes
Medical research
Research and Report: Traditional Chinese Medicine and Neuroregeneration
Surgery
修复
免疫反应
小鼠
巴西
循环免疫复合物
神经损伤
腹腔注射
Brazil
United States > US
China
Brazil
repair
peripheral nerve injury
immune
neural regeneration
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ISSN1673-5374
1876-7958
DOI10.3969/j.issn.1673-5374.2012.09.006

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Summary:BALB/c mice were intraperitoneally injected with 10, 5 or 2.5 mg/kg Brazil for 14 days after sciatic nerve injury. Results demonstrate that the spleen T/B lymphocyte stimulation index and serum circulating immune complex concentration were significantly reduced, and the morphology of the soleus muscle was restored in mice with sciatic nerve injury. These effects of Brazil were dose-dependent. Our experimental findings indicate that Brazil can regulate immune responses after nerve injury and promote sciatic nerve repair.
Bibliography:BALB/c mice were intraperitoneally injected with 10, 5 or 2.5 mg/kg Brazil for 14 days after sciatic nerve injury. Results demonstrate that the spleen T/B lymphocyte stimulation index and serum circulating immune complex concentration were significantly reduced, and the morphology of the soleus muscle was restored in mice with sciatic nerve injury. These effects of Brazil were dose-dependent. Our experimental findings indicate that Brazil can regulate immune responses after nerve injury and promote sciatic nerve repair.
Brazil peripheral nerve injury repair neural regeneration immune
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Jian Cao, M.D., Attending physician, Second Department of Orthopedics, Chifeng Municipal Hospital, Chifeng 024000, Inner Mongolia Autonomous Region, China
Jian Cao and Zhongping Niu contributed equally to this work.
Author contributions: Jian Cao had full access to data acquisition, integration and analysis, as well as study concept and design, and he wrote the manuscript. Lisen Li and Yongan Wang integrated data. Yiwen Jiang was responsible for data analysis. Zhongpin Niu and Weitian Yin validated papers. Haoyu Liu was responsible for statistical analysis. Lisen Li was in charge of funds. Binfeng Wang provided technical and information support. Weitian Yin instructed the experiments.
ISSN:1673-5374
1876-7958
DOI:10.3969/j.issn.1673-5374.2012.09.006