Mussel-inspired “plug-and-play” hydrogel glue for postoperative tumor recurrence and wound infection inhibition

• Published in: Journal of colloid and interface science Vol. 650; no. Pt B; pp. 1907 - 1917
• Main Authors: Li, Zimu, Yang, Li, Zhang, Dan, Wang, Wenyan, Huang, Qili, Liu, Qingyun, Shi, Kexin, Yu, Yongkang, Gao, Nansha, Chen, Hongzhong, Jiang, Shaoyun, Xie, Zhongjian, Zeng, Xiaowei
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.11.2023
• Subjects: Black phosphorus; Polyphenol-based hydrogels; Recurrence inhibition; Tumor therapy; Wound healing; Recurrence inhibition; Polyphenol-based hydrogels; Wound healing; Tumor therapy; Black phosphorus
• ISSN: 0021-9797; 1095-7103
• DOI: 10.1016/j.jcis.2023.07.154

[Display omitted] •The hydrogel effectively prevents postoperative tumor recurrence and wound infection.•The design of polyphenol endows the system with tissue adhesion and biocompatibility.•Pluronic® F127 component contributes to the thermo-responsiveness and injectability.•The “plug and play” property of the hydrogel enhances the efficiency of surgery. Currently, clinical tumor resection is faced with two options: open and minimally invasive surgery. Open surgery is easy to completely remove the lesion but is prone to infection, while minimally invasive surgery recovers faster but may cause tumor recurrence. To fill the shortcomings of the two surgical modes and make the choice for tumor resection more effortlessly, we developed a postoperative black phosphorus-Ag nanocomposites-loaded dopamine-modified hyaluronic acid-Pluronic® F127 (BP-Ag@HA-DA-Plu) hydrogel implantation system that can prevent tumor recurrence and wound infection simultaneously. Experiments have shown that the hydrogel system combined with 808 nm near-infrared (NIR) irradiation has excellent anti-tumor, antibacterial, and wound healing abilities. Additionally, unlike existing surgical hydrogel products that require inconvenient in-situ cross-linking, the BP-Ag@HA-DA-Plu hydrogel system offers “plug-and-play” functionality during surgery due to its thermo-responsiveness, injectability, and adhesion, thereby greatly improving the efficiency of surgery.