Characteristics and comparison between diabetes mellitus and non-diabetes mellitus among chronic kidney disease patients: A cross-sectional study of the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)

• Published in: Oncotarget Vol. 8; no. 63; pp. 106324 - 106332
• Main Authors: Zhang, Jun-Jun, Yang, Liu, Huang, Jun-Wen, Liu, Yu-Jie, Wang, Jin-Wei, Zhang, Lu-Xia, Zhao, Ming-Hui, Liu, Zhang-Suo
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 05.12.2017
• Subjects: Research Paper; chronic kidney disease; diabetes mellitus; medication; clinical traits; diabetic nephropathy
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.22368

Although the prevalence of chronic kidney disease (CKD) and diabetes mellitus (DM) is increasing globally, information on Chinese CKD patients with DM is lacking. A total of 3499 pre-dialysis CKD patients from across China were enrolled in the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) between November 2011 and April 2016. We divided the C-STRIDE patients into CKD with DM and CKD without DM groups and compared their clinical, demographic, and laboratory data in this cross-sectional study. CKD patients with DM were older, had a higher male-to-female ratio, and had more complications than CKD patients without DM. Age, smoking, and 24-h urinary protein levels were associated with co-occurrence of CKD and DM. Less than 50% of patients in either group took antilipemic, cardiovascular, cerebrovascular, or anti-anemic drugs. In addition, only 18.38% of CKD patients with DM had undergone a renal biopsy, and diabetic nephropathy was confirmed in 35.4% of them. Our findings suggest that several types of medication and renal biopsies should be used more frequently in the treatment of Chinese CKD patients with DM.