Arterial Infusion Chemotherapy in Patient with Repeated Recurrent Tumor of Cecal Cancer: Report of a Case

• Published in: Cancer investigation Vol. 26; no. 10; pp. 999 - 1001
• Main Authors: Ogawa, Masaichi, Takao, Yoshihiko, Watanabe, Michiaki, Eto, Ken, Yamagata, Tetsuya, Ushigome, Takurou, Anazawa, Sadao, Yanaga, Katsuhiko
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2008; Taylor & Francis
• Subjects: Antimetabolites, Antineoplastic - administration & dosage; Antimetabolites, Antineoplastic - therapeutic use; Arterial Infusion chemotherapy; Cecal Neoplasms - diagnostic imaging; Cecal Neoplasms - drug therapy; Cecal Neoplasms - surgery; Colon cancer; Female; Fluorodeoxyglucose F18; Fluorouracil - administration & dosage; Fluorouracil - therapeutic use; Humans; Infusions, Intra-Arterial; Middle Aged; Neoplasm Recurrence, Local; Radiopharmaceuticals; Recurrent Tumor; Tomography, X-Ray Computed; Treatment Outcome
• ISSN: 0735-7907; 1532-4192
• DOI: 10.1080/07357900802086731

Purpose: We report a patient with a repeated recurrent tumor after Right-hemicolectomy for advanced cecal cancer who was treated by intra-arterial infusions of 5-fluorouracil (5-FU). Methods: A computed tomography scan revealed a pelvic mass involving the psoas major muscle and quadratos lumborum muscle, in contact with the widely projecting toward L2-S2. The fluorodeoxyglucose-positron emission tomography (FDG-PET) revealed an accumulation spot in the same place. This case was deemed in operable, and one-shot bolus of 5-FU was administered through the tumor feeding arteries: the left 3rd, 4th lumbar, and ilio - lumbar arteries at a dosage of 250 mg/body from each artery. Results: A partial regression of the tumor was observed by computed tomography. The serum level of carbohydrate antigen 19-9 returned normal in 8 months. During chemotherapy, the side effect and complications were tolerable, and she experienced only grade-1 nausea caused by 5-fluorouracil. Conclusion: A long-time, intra-arterial 5-fluorouracil infusion could control effectively and safely.