Candesartan Cilexetil Determination by Electrode Modified with Hybrid Film of Ionic Liquid- Graphene Nanosheets-Silicon Carbide Nanoparticle Using Continuous Coulometric FFT Cyclic Voltammetry
In this work, a new electrochemical method is introduced for the determination of Candesartan cilexetil using a new sensor and Continuous Coulometric Fast Fourier transformation cyclic voltammetry (CCFFTCV). The new sensor was designed based on silicon carbide nanoparticles and graphene nanosheets h...
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Published in | International journal of electrochemical science Vol. 8; no. 2; pp. 2023 - 2033 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
01.02.2013
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Subjects | |
Online Access | Get full text |
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Summary: | In this work, a new electrochemical method is introduced for the determination of Candesartan cilexetil using a new sensor and Continuous Coulometric Fast Fourier transformation cyclic voltammetry (CCFFTCV). The new sensor was designed based on silicon carbide nanoparticles and graphene nanosheets hybrid mixed with ionic liquid (1-Butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]) on a glassy carbon electrode. The sensor response calculated in form of coulomb by integrating the charge changes under the peak current in a selected potential range. The experimental conditions, for the electrochemical measurement were optimized. The linear concentrations range of Candesartan cilexetil was from 0.5 to 120×10−8 M with a detection limit of 5.2×10−9 M. Moreover, the proposed sensor exhibits good accuracy, the response time less than 6s, high sensitivity with repeatability (R.S.D value of 3.5%) and long term stability, 55 days with a decrease of 2.3% in the response. |
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ISSN: | 1452-3981 1452-3981 |
DOI: | 10.1016/S1452-3981(23)14287-8 |