Candesartan Cilexetil Determination by Electrode Modified with Hybrid Film of Ionic Liquid- Graphene Nanosheets-Silicon Carbide Nanoparticle Using Continuous Coulometric FFT Cyclic Voltammetry

• Published in: International journal of electrochemical science Vol. 8; no. 2; pp. 2023 - 2033
• Main Authors: Norouzi, P., Pirali-Hamedani, M., Ganjali, M.R.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.02.2013
• Subjects: Candesartan cilexetil; FFT cyclic Voltammetry; Graphene nanosheets; Ionic liquid; Silicon carbide nanoparticles; Candesartan cilexetil; Graphene nanosheets; Silicon carbide nanoparticles; FFT cyclic Voltammetry; Ionic liquid
• ISSN: 1452-3981; 1452-3981
• DOI: 10.1016/S1452-3981(23)14287-8

In this work, a new electrochemical method is introduced for the determination of Candesartan cilexetil using a new sensor and Continuous Coulometric Fast Fourier transformation cyclic voltammetry (CCFFTCV). The new sensor was designed based on silicon carbide nanoparticles and graphene nanosheets hybrid mixed with ionic liquid (1-Butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]) on a glassy carbon electrode. The sensor response calculated in form of coulomb by integrating the charge changes under the peak current in a selected potential range. The experimental conditions, for the electrochemical measurement were optimized. The linear concentrations range of Candesartan cilexetil was from 0.5 to 120×10−8 M with a detection limit of 5.2×10−9 M. Moreover, the proposed sensor exhibits good accuracy, the response time less than 6s, high sensitivity with repeatability (R.S.D value of 3.5%) and long term stability, 55 days with a decrease of 2.3% in the response.