The effect of cyclophosphamide on suppressor cells in guinea pigs

• Published in: Cellular immunology Vol. 33; no. 2; pp. 402 - 411
• Main Authors: Neta, Ruth, Winkelstein, A., Salvin, S.B., Mendelow, H.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.10.1977
• Subjects: Animals; Cyclophosphamide - pharmacology; Female; Guinea Pigs; Immunity, Cellular; Immunosuppression; Lymphoid Tissue - immunology; Spleen - immunology; T-Lymphocytes - immunology; Thymus Gland - pathology

Treatment of guinea pigs with cyclophosphamide is known to deplete lymphoid tissues, although its effect on delayed hypersensitivity is varied. Experiments were conducted in which suppressor cell activity was studied in vitro in association with histological changes in different lymphoid tissues. An...