The effect of cyclophosphamide on suppressor cells in guinea pigs
Treatment of guinea pigs with cyclophosphamide is known to deplete lymphoid tissues, although its effect on delayed hypersensitivity is varied. Experiments were conducted in which suppressor cell activity was studied in vitro in association with histological changes in different lymphoid tissues. An...
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Published in | Cellular immunology Vol. 33; no. 2; pp. 402 - 411 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Inc
01.10.1977
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Subjects | |
Online Access | Get full text |
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Summary: | Treatment of guinea pigs with cyclophosphamide is known to deplete lymphoid tissues, although its effect on delayed hypersensitivity is varied. Experiments were conducted in which suppressor cell activity was studied
in vitro in association with histological changes in different lymphoid tissues. An inverse relationship existed between the number of thymic lymphoid cells and thymic suppressor cell activity. In the spleens, suppressor cell activity was also observed initially, but its course could not be followed because of increased myelopoietic action. |
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ISSN: | 0008-8749 1090-2163 |
DOI: | 10.1016/0008-8749(77)90168-X |