The effect of cyclophosphamide on suppressor cells in guinea pigs

Treatment of guinea pigs with cyclophosphamide is known to deplete lymphoid tissues, although its effect on delayed hypersensitivity is varied. Experiments were conducted in which suppressor cell activity was studied in vitro in association with histological changes in different lymphoid tissues. An...

Full description

Saved in:
Bibliographic Details
Published inCellular immunology Vol. 33; no. 2; pp. 402 - 411
Main Authors Neta, Ruth, Winkelstein, A., Salvin, S.B., Mendelow, H.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.10.1977
Subjects
Animals
Cyclophosphamide - pharmacology
Female
Guinea Pigs
Immunity, Cellular
Immunosuppression
Lymphoid Tissue - immunology
Spleen - immunology
T-Lymphocytes - immunology
Thymus Gland - pathology
Online AccessGet full text

Cover

More Information
Summary:Treatment of guinea pigs with cyclophosphamide is known to deplete lymphoid tissues, although its effect on delayed hypersensitivity is varied. Experiments were conducted in which suppressor cell activity was studied in vitro in association with histological changes in different lymphoid tissues. An inverse relationship existed between the number of thymic lymphoid cells and thymic suppressor cell activity. In the spleens, suppressor cell activity was also observed initially, but its course could not be followed because of increased myelopoietic action.
ISSN:0008-8749
1090-2163
DOI:10.1016/0008-8749(77)90168-X