Rapidly Dissolving Microneedle Patches for Transdermal Iron Replenishment Therapy

• Published in: Journal of pharmaceutical sciences Vol. 107; no. 6; pp. 1642 - 1647
• Main Authors: Maurya, Abhijeet, Nanjappa, Shivakumar H., Honnavar, Swati, Salwa, M., Murthy, S. Narasimha
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2018
• Subjects: dissolution; drug delivery systems; formulation; in vitro models; kinetics; microneedles; skin; transdermal drug delivery; drug delivery systems; in vitro models; transdermal drug delivery; dissolution; microneedles; skin; formulation; kinetics
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1016/j.xphs.2018.02.011

The prevalence of iron deficiency anemia (IDA) is predominant in women and children especially in developing countries. The disorder affects cognitive functions and physical activity. Although oral iron supplementation and parenteral therapy remains the preferred choice of treatment, gastric side effects and risk of iron overload decreases adherence to therapy. Transdermal route is an established approach, which circumvents the side effects associated with conventional therapy. In this project, an attempt was made to investigate the use of rapidly dissolving microneedles loaded with ferric pyrophosphate (FPP) as a potential therapeutic approach for management of IDA. Microneedle array patches were made using the micromolding technique and tested in vitro using rat skin to check the duration required for dissolution/disappearance of needles. The ability of FPP-loaded microneedles to replenish iron was investigated in anemic rats. Rats were fed iron-deficient diet for 5 weeks to induce IDA following which microneedle treatment was initiated. Recovery of rats from anemic state was monitored by measuring hematological and biochemical parameters. Results from in vivo study displayed significant improvements in hemoglobin and serum iron levels after 2-week treatment with FPP-loaded microneedles. The study effectively demonstrated the potential of microneedle-mediated iron replenishment for treatment of IDA.