Application of Multiparametric Quantitative Cardiac Magnetic Resonance for Detection and Monitoring of Myocardial Injury in Patients with Fulminant Myocarditis

• Published in: Academic radiology Vol. 28; no. 2; p. e35
• Main Authors: Li, Haojie, Zhu, Hui, Yang, Zhaoxia, Tang, Dazhong, Huang, Lu, Xia, Liming
• Format: Journal Article
• Language: English
• Published: United States 01.02.2021
• Subjects: Case-Control Studies; Contrast Media; Female; Gadolinium; Humans; Magnetic Resonance Imaging, Cine; Magnetic Resonance Spectroscopy; Male; Myocarditis - diagnostic imaging; Predictive Value of Tests; Prospective Studies; Myocarditis; Inflammation; Magnetic resonance imaging; Strain
• ISSN: 1878-4046
• DOI: 10.1016/j.acra.2020.01.034

To investigate whether multiparametric cardiac magnetic resonance (CMR) could detect and monitor inflammatory myocardial alterations in fulminant myocarditis. Nineteen patients (35 ± 14 years, 37% male) with clinical diagnosis of fulminant myocarditis underwent CMR examinations at 3.0T in the acute phase and at 3-months follow up. The control group consisted of 19 healthy volunteers. The CMR protocol included cine, black blood T2-weighted imaging, T1 mapping, T2 mapping and late gadolinium enhancement (LGE). Cardiac parameters, such as edema ratio, LGE mass, native T1, T2 and extracellular volume were measured. The left ventricular mass index (67 ± 15 versus 55 ± 12 g/m , p < 0.05) and interventricular septum thickness (10.4 ± 1.5 versus 8.3 ± 1.8 mm, p < 0.001) in acute stage was significantly higher compared to controls, and normalized at the chronic stage. All quantitative inflammation metrics, including edema ratio, LGE mass, native T1, T2 and extracellular volume were significantly (all p < 0.001) decreased in the follow-up scan, but still higher compared to controls. Compared to the controls, all global strain indices including circumferential, longitudinal and radial strain values were significantly impaired in acute stage (all p < 0.001). Native T1 and T2 values led to excellent diagnostic accuracy for discriminating fulminant myocarditis from healed myocarditis, with AUC of 0.947 and 0.931. Multiparametric CMR could detect and monitor inflammation myocardial injuries in patients with fulminant myocarditis. Native T1 and T2 values achieved excellent diagnostic performance in distinguishing acute from healed myocarditis.