Non-tuberculous Mycobacteriosis with T-cell Lymphoma in a Red Panda (Ailurus fulgens)

A 9-year-old male red panda (Ailurus fulgens) became emaciated and died. Necropsy examination revealed systemic lymphadenomegaly. The liver, lungs and left kidney contained multifocal yellow nodules. Microscopical examination revealed granulomatous inflammation in the liver, lungs, kidney, spleen an...

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Published inJournal of comparative pathology Vol. 155; no. 2-3; pp. 263 - 266
Main Authors Fuke, N., Hirai, T., Makimura, N., Goto, Y., Habibi, W.A., Ito, S., Trang, N.T., Koshino, K., Takeda, M., Yamaguchi, R.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2016
Subjects
Ailuridae - microbiology
Animals
Animals, Zoo - microbiology
Lymphoma, T-Cell - veterinary
Male
Mycobacterium
Mycobacterium gastri
Mycobacterium Infections - veterinary
non-tuberculous mycobacteriosis
red panda
T-cell lymphoma
red panda
non-tuberculous mycobacteriosis
T-cell lymphoma
Mycobacterium gastri
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Summary:A 9-year-old male red panda (Ailurus fulgens) became emaciated and died. Necropsy examination revealed systemic lymphadenomegaly. The liver, lungs and left kidney contained multifocal yellow nodules. Microscopical examination revealed granulomatous inflammation in the liver, lungs, kidney, spleen and lymph nodes, with numerous acid-fast bacilli. Sequencing of genetic material isolated from the tissues classified the pathogen as Mycobacterium gastri. Lymphoma was found in the liver, lungs, kidney and lymph nodes. The neoplastic cells were strongly labelled for expression of CD3, Ki67 and proliferating cell nuclear antigen by immunohistochemistry. This is the first report of M. gastri infection with T-cell lymphoma in a red panda.
Bibliography:ObjectType-Case Study-2
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ISSN:0021-9975
1532-3129
DOI:10.1016/j.jcpa.2016.06.001