Dexmedetomidine: clinical application as an adjunct for intravenous regional anesthesia

• Published in: Anesthesiology clinics Vol. 28; no. 4; p. 709
• Main Authors: Ramadhyani, Usha, Park, Jason L, Carollo, Dominic S, Waterman, Ruth S, Nossaman, Bobby D
• Format: Journal Article
• Language: English
• Published: United States 01.12.2010
• Subjects: Adjuvants, Anesthesia - pharmacology; Anesthesia, Conduction - methods; Animals; Dexmedetomidine - administration & dosage; Dexmedetomidine - pharmacology; Dexmedetomidine - toxicity; Humans
• ISSN: 1932-2275
• DOI: 10.1016/j.anclin.2010.08.008

The selective α-2 adrenoceptor agonist, dexmedetomidine, has been shown to be a useful, safe adjunct in perioperative medicine. Intravenous regional anesthesia is one of the simplest forms of regional anesthesia and has a high degree of success. However, intravenous regional anesthesia is limited by the development of tourniquet pain and its inability to provide postoperative analgesia. To improve block quality, prolong postdeflation analgesia, and decrease tourniquet pain, various chemical additives have been combined with local anesthetics, although with limited success. The antinociceptive effects of α-2 adrenoceptor agonists have been shown in animals and in humans. However, less is known about the clinical effects of dexmedetomidine when coadministered with local anesthetics in patients undergoing intravenous regional anesthesia. This review examines what is currently known to improve our understanding of the properties and application of dexmedetomidine when used as an adjunct in intravenous regional anesthesia.