Radioligands targeting purinergic P2X7 receptor

• Published in: Bioorganic & medicinal chemistry letters Vol. 30; no. 12; p. 127169
• Main Author: Zheng, Qi-Huang
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.06.2020
• Subjects: Drug discovery; Molecular imaging; Positron emission tomography (PET); Purinergic P2X7 receptor (P2X7R); Radioligands; Single photon emission computed tomography (SPECT); Purinergic P2X7 receptor (P2X7R); Molecular imaging; Radioligands; Positron emission tomography (PET); Drug discovery; Single photon emission computed tomography (SPECT)

[Display omitted] The purinergic P2X7 receptor (P2X7R) is an adenosine triphosphate (ATP) ligand-gated cationic channel receptor. P2X7R is closely associated with various inflammatory, immune, cancer, neurological, musculoskeletal and cardiovascular disorders. P2X7R is an interesting therapeutic tar...