Radioligands targeting purinergic P2X7 receptor

[Display omitted] The purinergic P2X7 receptor (P2X7R) is an adenosine triphosphate (ATP) ligand-gated cationic channel receptor. P2X7R is closely associated with various inflammatory, immune, cancer, neurological, musculoskeletal and cardiovascular disorders. P2X7R is an interesting therapeutic tar...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 30; no. 12; p. 127169
Main Author Zheng, Qi-Huang
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 15.06.2020
Subjects
Drug discovery
Molecular imaging
Positron emission tomography (PET)
Purinergic P2X7 receptor (P2X7R)
Radioligands
Single photon emission computed tomography (SPECT)
Purinergic P2X7 receptor (P2X7R)
Molecular imaging
Radioligands
Positron emission tomography (PET)
Drug discovery
Single photon emission computed tomography (SPECT)
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Summary:[Display omitted] The purinergic P2X7 receptor (P2X7R) is an adenosine triphosphate (ATP) ligand-gated cationic channel receptor. P2X7R is closely associated with various inflammatory, immune, cancer, neurological, musculoskeletal and cardiovascular disorders. P2X7R is an interesting therapeutic target as well as molecular imaging target. This brief digest highlights the radioligands targeting P2X7R recently developed in drug discovery and molecular imaging agent development.
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ISSN:0960-894X
1464-3405
1464-3405
DOI:10.1016/j.bmcl.2020.127169