Microbiota and plant-derived vesicles that serve as therapeutic agents and delivery carriers to regulate metabolic syndrome

• Published in: Advanced drug delivery reviews Vol. 196; p. 114774
• Main Authors: Niu, Guanting, Jian, Tunyu, Gai, Yanan, Chen, Jian
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2023
• Subjects: Applied engineering; Diabetes; Drug delivery carrier; Extracellular Vesicles; Gastrointestinal Microbiome; Gut homeostasis; Humans; Metabolic Diseases; Metabolic Syndrome - drug therapy; Microbiota; Obesity - drug therapy; Plant-derived extracellular vesicles (PDEVs); Plant-derived extracellular vesicles (PDEVs); Diabetes; Applied engineering; Gut homeostasis; Drug delivery carrier
• ISSN: 0169-409X; 1872-8294
• DOI: 10.1016/j.addr.2023.114774

[Display omitted] The gut is a fundamental organ in controlling human health. Recently, researches showed that substances in the intestine can alter the course of many diseases through the intestinal epithelium, especially intestinal flora and exogenously ingested plant vesicles that can be transported over long distances to various organs. This article reviews the current knowledge on extracellular vesicles in modulating gut homeostasis, inflammatory response and numerous metabolic disease that share obesity as a co-morbidity. These complex systemic diseases that are difficult to cure, but can be managed by some bacterial and plant vesicles. Vesicles, due to their digestive stability and modifiable properties, have emerged as novel and targeted drug delivery vehicles for effective treatment of metabolic diseases.