Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus

This study sought to investigate the effects of Purendan superfine powder comprised of Momordica charantia, Radix Ginseng, and Radix Salviae Miltiorrhiae on neuronal apoptosis and expression of bcl-2, bax, and caspase-3, which are retinal apoptosis-associated factors in rats with diabetes mellitus i...

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Published inNeural regeneration research Vol. 7; no. 3; pp. 202 - 206
Main Authors Dong, Zhijun, Tao, Xiangyi, Fu, Xiaoxiao, Wang, Haibin, Wang, Donghua, Zhang, Tiemin
Format Journal Article
LanguageEnglish
Published India Medknow Publications & Media Pvt. Ltd 25.01.2012
Department of Ophthalmology, Chengde Medical College Affiliated Hospital, Chengde 067000, Hebei Province, China
Medknow Publications & Media Pvt Ltd
Subjects
2型糖尿病
Apoptosis
bcl-2蛋白
caspase-3
Diabetes
Diabetic retinopathy
Genes
Laboratory animals
Protein expression
Proteins
Research and Report: Traditional Chinese Medicine and Neuroregeneration
Retina
Rodents
保护作用
神经细胞凋亡
糖尿病大鼠
糖尿病视网膜病变
超细粉
Beijing China
Switzerland
China
bax
cellular apoptosis
bcl-2
Purendan superfine powder
diabetic retinopathy
caspase-3
cellular apoptosiszhangtiemin1956@126.com
Online AccessGet full text
ISSN1673-5374
1876-7958
DOI10.3969/j.issn.1673-5374.2012.03.008

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Summary:This study sought to investigate the effects of Purendan superfine powder comprised of Momordica charantia, Radix Ginseng, and Radix Salviae Miltiorrhiae on neuronal apoptosis and expression of bcl-2, bax, and caspase-3, which are retinal apoptosis-associated factors in rats with diabetes mellitus induced by continuous intraperitoneal injection of streptozotocin. The results showed that Purendan superfine powder could upregulate the expression of bcl-2 protein and mRNA, and downregulate the expression of bax and caspase-3 in the retina of diabetes mellitus rats. In addition, Purendan superfine powder was shown to reduce the number of apoptotic neurons. Our experimental findings indicate that Purendan superfine powder can inhibit neuronal apoptosis in the retina of diabetes mellitus rats and has protective effects on diabetic retinopathy.
Bibliography:Purendan superfine powder; diabetic retinopathy; bcl-2; bax; caspase-3; cellular apoptosis
This study sought to investigate the effects of Purendan superfine powder comprised of Momordica charantia, Radix Ginseng, and Radix Salviae Miltiorrhiae on neuronal apoptosis and expression of bcl-2, bax, and caspase-3, which are retinal apoptosis-associated factors in rats with diabetes mellitus induced by continuous intraperitoneal injection of streptozotocin. The results showed that Purendan superfine powder could upregulate the expression of bcl-2 protein and mRNA, and downregulate the expression of bax and caspase-3 in the retina of diabetes mellitus rats. In addition, Purendan superfine powder was shown to reduce the number of apoptotic neurons. Our experimental findings indicate that Purendan superfine powder can inhibit neuronal apoptosis in the retina of diabetes mellitus rats and has protective effects on diabetic retinopathy.
11-5422/R
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Author contributions: Zhijun Dong had full access to the study concept and design, implemented molecular biological experiments, conducted data analysis, and wrote the manuscript. Xiangyi Tao and Xiaoxiao Fu were responsible for data analysis and statistical processing. Haibin Wang and Donghua Wang participated in feeding and processing experimental animals, and provided information. Tiemin Zhang participated in the study concept and design, and supervised the study.
Zhijun Dong, Master, Attending physician, Department of Ophthalmology, Chengde Medical College Affiliated Hospital, Chengde 067000, Hebei Province, China
ISSN:1673-5374
1876-7958
DOI:10.3969/j.issn.1673-5374.2012.03.008