Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer

• Published in: Oncotarget Vol. 8; no. 25; pp. 41701 - 41716
• Main Author: Meng, Jianghui
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 20.06.2017
• Subjects: Biological Transport; Carcinogenesis; Dynamins - metabolism; Humans; Neoplasms - genetics; Protein Isoforms - genetics; Review; endocytosis; cancer target; amphiphysin; clathrin; tumor
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.16678

Dynamins and their related proteins participate in the regulation of neurotransmission, antigen presentation, receptor internalization, growth factor signalling, nutrient uptake, and pathogen infection. Recently, emerging findings have shown dynamin proteins can also contribute to the genesis of cancer. This up-to-date review herein focuses on the functionality of dynamin in cancer development. Dynamin 1 and 2 both enhance cancer cell proliferation, tumor invasion and metastasis, whereas dynamin 3 has tumor suppression role. Antisense RNAs encoded on the DNA strand opposite a dynamin gene regulate the function of dynamin, and manipulate oncogenes and tumor suppressor genes. Certain dynamin-related proteins are also upregulated in distinct cancer conditions, resulting in apoptotic resistance, cell migration and poor prognosis. Altogether, dynamins are potential biomarkers as well as representing promising novel therapeutic targets for cancer treatment. This study also summarizes the current available dynamin-targeted therapeutics and suggests the potential strategy based on signalling pathways involved, providing important information to aid the future development of novel cancer therapeutics by targeting these dynamin family members.