Discovery of benzotriazole-azo-phenol/aniline derivatives as antifungal agents

[Display omitted] A series of benzotriazole-azo-phenol/aniline derivatives were prepared and evaluated for their antifungal activities against six phytopathogenic fungi such as Fusarium graminearum, Fusarium solani, Alternaria alternate, Valsa mali, Botrytis cinerea, and Curvularia lunata. Among the...

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Published inBioorganic & medicinal chemistry letters Vol. 28; no. 2; pp. 181 - 187
Main Authors Lv, Min, Ma, Jingchun, Li, Qin, Xu, Hui
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 15.01.2018
Elsevier
Subjects
Antifungal activity
Benzotriazole
Benzotriazole-azo-aniline
Benzotriazole-azo-phenol
Chemistry
Chemistry, Medicinal
Chemistry, Organic
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Physical Sciences
Protective effects
Science & Technology
Therapeutic effect
Antifungal activity
Benzotriazole-azo-phenol
Protective effects
Therapeutic effect
Benzotriazole
Benzotriazole-azo-aniline
DESIGN
INSECTICIDAL AGENTS
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Summary:[Display omitted] A series of benzotriazole-azo-phenol/aniline derivatives were prepared and evaluated for their antifungal activities against six phytopathogenic fungi such as Fusarium graminearum, Fusarium solani, Alternaria alternate, Valsa mali, Botrytis cinerea, and Curvularia lunata. Among them, compounds IIf, IIn, and IIr showed a broad-spectrum of potent antifungal activities. Especially some compounds displayed 3.5–10.8 folds more potent activities than carbendazim against A. alternata and C. lunata. Notably, compounds IIc, IIm, and IIr exhibited good protective and therapeutic effects against B. cinerea at 200 μg/mL. Their structure-activity relationships were also discussed.
Bibliography:ObjectType-Article-1
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ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2017.11.032