Studies on anti-angiogenesis of ginsenoside structure modification HRG in vitro
This study investigates the anti-angiogenic effect of 3β, 12β, 20(S)-trihydroxy dammarane-3-O-β-d-glucopyranosyl(1–2)-β-d-glucopyranoside(HRG), a new chemical compound obtained by structure modification on Ginseng saponins Rg3, associated with the regulation of matrix metalloproteinases(MMPs) and it...
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Published in | Biochemical and biophysical research communications Vol. 492; no. 3; pp. 391 - 396 |
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Main Authors | , , , , , , |
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Language | English |
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21.10.2017
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Abstract | This study investigates the anti-angiogenic effect of 3β, 12β, 20(S)-trihydroxy dammarane-3-O-β-d-glucopyranosyl(1–2)-β-d-glucopyranoside(HRG), a new chemical compound obtained by structure modification on Ginseng saponins Rg3, associated with the regulation of matrix metalloproteinases(MMPs) and its upstream signal-regulated molecule of vascular endothelial growth factor(VEGF) and basic fibroblast growth factor(b-FGF) in vitro, which plays an critical role in angiogenesis during the process of carcinoma. In our study, to investigate the anti-angiogenesis effect of HRG in HUVECs, we utilized cell proliferation assay, tube formation assay, wound-healing assay, Semi-quantitative reverse transcription PCR, and Western blot assay. Our results demonstrated that HRG plays a major role in the regulation of proliferation, migration and tube formation of HUVECs by suppressing the expression of VEGF and b-FGF in both transcriptional and post-transcriptional levels. In addition, the expression of MMP-2 and MMP-9, which were related to the ECM degradation, were down-regulated after administration of HRG as well. Overall, our results revealed that HRG strongly inhibited the process of angiogenesis and shows better effectiveness than Rg3. |
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AbstractList | This study investigates the anti-angiogenic effect of 3β, 12β, 20(S)-trihydroxy dammarane-3-O-β-d-glucopyranosyl(1-2)-β-d-glucopyranoside(HRG), a new chemical compound obtained by structure modification on Ginseng saponins Rg3, associated with the regulation of matrix metalloproteinases(MMPs) and its upstream signal-regulated molecule of vascular endothelial growth factor(VEGF) and basic fibroblast growth factor(b-FGF) in vitro, which plays an critical role in angiogenesis during the process of carcinoma. In our study, to investigate the anti-angiogenesis effect of HRG in HUVECs, we utilized cell proliferation assay, tube formation assay, wound-healing assay, Semi-quantitative reverse transcription PCR, and Western blot assay. Our results demonstrated that HRG plays a major role in the regulation of proliferation, migration and tube formation of HUVECs by suppressing the expression of VEGF and b-FGF in both transcriptional and post-transcriptional levels. In addition, the expression of MMP-2 and MMP-9, which were related to the ECM degradation, were down-regulated after administration of HRG as well. Overall, our results revealed that HRG strongly inhibited the process of angiogenesis and shows better effectiveness than Rg3. |
Author | Sun, Ting-ting Liu, Mo-xiang Zhu, Lei Yuan, Ye Li, Ji-ping Zhang, Wen-you Zhao, Feng-li |
Author_xml | – sequence: 1 givenname: Ji-ping surname: Li fullname: Li, Ji-ping email: jipingli2005@126.com organization: Department of Pharmacology, Medical College, Yangzhou University, Yangzhou 225001, Jiangsu, China – sequence: 2 givenname: Feng-li surname: Zhao fullname: Zhao, Feng-li organization: Department of Pharmacology, Medical College, Yangzhou University, Yangzhou 225001, Jiangsu, China – sequence: 3 givenname: Ye surname: Yuan fullname: Yuan, Ye organization: Department of Pharmacology, Medical College, Yangzhou University, Yangzhou 225001, Jiangsu, China – sequence: 4 givenname: Ting-ting surname: Sun fullname: Sun, Ting-ting organization: Department of Pharmacology, Medical College, Yangzhou University, Yangzhou 225001, Jiangsu, China – sequence: 5 givenname: Lei surname: Zhu fullname: Zhu, Lei organization: Department of Pharmacology, Medical College, Yangzhou University, Yangzhou 225001, Jiangsu, China – sequence: 6 givenname: Wen-you surname: Zhang fullname: Zhang, Wen-you organization: Department of Pharmacology, Medical College, Yangzhou University, Yangzhou 225001, Jiangsu, China – sequence: 7 givenname: Mo-xiang surname: Liu fullname: Liu, Mo-xiang organization: Institute of Drug Research, Medical College, Yangzhou University, Yangzhou 225001, Jiangsu, China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28847727$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1016_j_jgr_2020_07_002 crossref_primary_10_1016_j_jgr_2022_08_003 crossref_primary_10_1007_s10529_022_03243_0 crossref_primary_10_3390_molecules25214905 crossref_primary_10_1016_j_bioorg_2021_105535 crossref_primary_10_3390_cancers13092223 crossref_primary_10_3389_fphar_2018_00423 crossref_primary_10_5650_jos_ess23120 |
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Keywords | Ginsenoside structure modification Cell proliferation Angiogenesis Migration VEGF HUVECs |
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Snippet | This study investigates the anti-angiogenic effect of 3β, 12β, 20(S)-trihydroxy dammarane-3-O-β-d-glucopyranosyl(1–2)-β-d-glucopyranoside(HRG), a new chemical... This study investigates the anti-angiogenic effect of 3β, 12β, 20(S)-trihydroxy dammarane-3-O-β-d-glucopyranosyl(1-2)-β-d-glucopyranoside(HRG), a new chemical... |
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SubjectTerms | Angiogenesis Cell proliferation Cell Proliferation - drug effects Cells, Cultured Dose-Response Relationship, Drug Ginsenoside structure modification Ginsenosides - chemistry Human Umbilical Vein Endothelial Cells - drug effects Humans HUVECs Migration Molecular Conformation Neovascularization, Pathologic - drug therapy Saponins - chemical synthesis Saponins - chemistry Saponins - pharmacology Structure-Activity Relationship VEGF |
Title | Studies on anti-angiogenesis of ginsenoside structure modification HRG in vitro |
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