A Retrospective Cohort Analysis of Hemorrhagic Arteriovenous Malformations Treated with Combined Endovascular Embolization and Gamma Knife Stereotactic Radiosurgery

• Published in: World neurosurgery Vol. 122; pp. e713 - e722
• Main Authors: Todnem, Nathan, Ward, Ayobami, Nahhas, Michael, Vender, John R., Alleyne, Cargill H., Rahimi, Scott Y.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2019
• Subjects: Adolescent; Adult; Aged; Arteriovenous Fistula - diagnostic imaging; Arteriovenous Fistula - therapy; Arteriovenous malformation; Cerebral Hemorrhage - diagnostic imaging; Cerebral Hemorrhage - therapy; Child; Cohort Studies; Embolization; Embolization, Therapeutic - methods; Endovascular; Female; Follow-Up Studies; Gamma knife; Humans; Intracranial Arteriovenous Malformations - diagnostic imaging; Intracranial Arteriovenous Malformations - therapy; Male; Middle Aged; Radiosurgery; Radiosurgery - methods; Retrospective Studies; Spetzler-Martin; Stereotactic; Treatment Outcome; Young Adult; GK; MRI; Endovascular; Radiosurgery; mRS; CT; SRS; AVM; Embolization; Spetzler-Martin; SM; Arteriovenous malformation; Stereotactic; Gamma knife
• ISSN: 1878-8750; 1878-8769
• DOI: 10.1016/j.wneu.2018.10.125

The management of brain arteriovenous malformations (AVMs) remains a controversial topic. Given the relatively low incidence, high heterogeneity, and high morbidity and mortality of these lesions, consensus on treatment strategies is an issue of concern to organized neurosurgery. The present retrospective analysis examined and quantified the outcomes of patients with an initial presentation of intracranial hemorrhage from a Spetzler-Martin grade III or IV AVM, later ruled out as surgical candidates. A total of 16 patients (5 females; 11 males) had presented with symptomatic hemorrhage confirmed by non–contrast-enhanced computed tomography and were deemed to not be surgical candidates owing to AVM location and/or architecture. The patients underwent combined endovascular embolization and gamma knife stereotactic radiosurgery (SRS). The modified Rankin scale was used to measure the clinical outcomes, comparing the scores at presentation, gamma knife treatment, and the last known follow-up examination. A radiographic evaluation was used to determine the level of AVM nidus involution after the procedure. The present study identified 16 patients with ruptured high-grade AVMs of high surgical risk. All the patients had undergone immediate embolization with delayed SRS for treatment of the hemorrhage and nidus of the AVM. A statistically significant proportion of patients showed marked improvement in the modified Rankin scale scores. No subsequent repeat hemorrhage or any associated complications after embolization occurred in any patient. These findings warrant consideration of endovascular embolization with adjuvant SRS as a powerful treatment option for cases with high surgical morbidity due to AVM characteristics.