APOL1 genotype, blood pressure, and survival in African Americans with nondiabetic nephropathy

Several landmark trials have assessed the effects of aggressive hypertension control on the progression of nondiabetic chronic kidney disease. Results generally have been disappointing. With the realization that lowering blood pressure, including with renin-angiotensin system blockade, failed to rel...

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Bibliographic Details
Published inKidney international Vol. 91; no. 2; pp. 276 - 278
Main Authors Robinson, Todd W., Freedman, Barry I.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.2017
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Summary:Several landmark trials have assessed the effects of aggressive hypertension control on the progression of nondiabetic chronic kidney disease. Results generally have been disappointing. With the realization that lowering blood pressure, including with renin-angiotensin system blockade, failed to reliably prevent end-stage kidney disease, studies now are analyzing longer-term effects of hypertension control on survival in chronic kidney disease. This commentary reviews the current findings and extends the discussion to apolipoprotein L1 gene by blood pressure (or gene by environment) interactions.
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ISSN:0085-2538
1523-1755
DOI:10.1016/j.kint.2016.10.027