Arisanschinins A-E, Lignans from Schisandra arisanensis Hay

• Published in: Planta medica Vol. 76; no. 14; pp. 1605 - 1610
• Main Authors: Liu, Chin-Cheng, Abd El-Razek, Mohamed H, Liaw, Chia-Ching, Cheng, Yuan-Bin, Chen, Chien-Kuang, Chien, Ching-Te, Kuo, Yao-Haur, Liou, Shorong-Shii, Shen, Ya-Ching
• Format: Journal Article
• Language: English
• Published: Germany 01.10.2010
• Subjects: aerial parts; alpha-glucosidase; antioxidant activity; Biphenyl Compounds - chemistry; chemical constituents of plants; chemical structure; Cyclooctanes - chemistry; Cyclooctanes - isolation & purification; Cyclooctanes - pharmacology; enzyme inhibitors; free radical scavengers; Free Radical Scavengers - chemistry; Free Radical Scavengers - isolation & purification; Free Radical Scavengers - pharmacology; lignans; Lignans - chemistry; Lignans - isolation & purification; Lignans - pharmacology; medicinal plants; medicinal properties; Nuclear Magnetic Resonance, Biomolecular; Picrates - chemistry; plant extracts; Plant Extracts - chemistry; quantitative analysis; Schisandra; Schisandra - chemistry; Schisandra arisanensis; Taiwan
• ISSN: 0032-0943; 1439-0221
• DOI: 10.1055/s-0029-1241014

Four new oxygenated dibenzocyclooctadiene lignans, arisanschinins A-D ( 1- 4), and a new 1,4-bis(phenyl)-2,3-dimethylbutane lignan, arisanschinin E ( 5), together with 15 known compounds, were isolated from the EtOAc-soluble fraction of the aerial parts of SCHISANDRA ARISANENSIS Hay. The structures of 1- 5 were elucidated on the basis of extensive spectroscopic analyses, including 2D NMR (HMQC, HMBC, and NOESY) experiments. The configurations of the biphenyl and octadiene moieties were deduced from circular dichroism (CD) and NOESY spectra, respectively. Compound 1 showed significant inhibition of α-glucosidase IN VITRO. The radical-scavenging activities of these compounds were evaluated using DPPH.