Immuno-oncology and Its Opportunities for Interventional Radiologists: Immune Checkpoint Inhibition and Potential Synergies with Interventional Oncology Procedures

Immunotherapy, specifically the use of immune checkpoint inhibitors, offers a new approach to fighting cancer. Although the results of treatment with immune checkpoint inhibition alone have been remarkable for certain cancers, these results are not universal. Preclinical and early clinical studies i...

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Published inJournal of vascular and interventional radiology Vol. 28; no. 11; pp. 1487 - 1494
Main Authors Hickey, Ryan M., Kulik, Laura M., Nimeiri, Halla, Kalyan, Aparna, Kircher, Sheetal, Desai, Kush, Riaz, Ahsun, Lewandowski, Robert J., Salem, Riad
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2017
Subjects
Combined Modality Therapy
Humans
Immunotherapy - methods
Medical Oncology
Neoplasms - diagnostic imaging
Neoplasms - immunology
Neoplasms - therapy
Radiology, Interventional
RT
MDSC
APC
RF
HCC
PDL
CTLA-4
HIF-1α
PD-1
DC
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Summary:Immunotherapy, specifically the use of immune checkpoint inhibitors, offers a new approach to fighting cancer. Although the results of treatment with immune checkpoint inhibition alone have been remarkable for certain cancers, these results are not universal. Preclinical and early clinical studies indicate the potential for synergistic effects when immune checkpoint inhibition is combined with immunogenic local therapies such as ablation and embolization. This review offers an overview of immunology as it relates to immune checkpoint inhibition and the possibilities for synergy when combined with interventional radiology treatments.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1051-0443
1535-7732
DOI:10.1016/j.jvir.2017.07.018