Zn-MOF: an efficient drug delivery platform for the encapsulation and releasing of Imatinib Mesylate

• Published in: Journal of porous materials Vol. 28; no. 2; pp. 641 - 649
• Main Authors: Arabbaghi, Erfan Khadem, Mokhtari, Javad, Naimi-Jamal, Mohammad Reza, Khosravi, Armaghan
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2021; Springer Nature B.V
• Subjects: Ball milling; Catalysis; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Electron microscopy; Emission analysis; Encapsulation; Field emission microscopy; Inductively coupled plasma; Microscopy; Physical Chemistry; Thermogravimetric analysis; X ray powder diffraction; BDC; Encapsulation; Zn; Imatinib mesylate; Drug delivery; Hydrolytic decomposition; Zn-MOF; DABCO
• ISSN: 1380-2224; 1573-4854
• DOI: 10.1007/s10934-020-01027-3

Mesoporous Zn 2 (BDC) 2 (DABCO)-MOF (BDC = 1,4-benzenedicarboxilic acid, and DABCO = diazabicyclooctane) was synthesized via ball-milling and employed as a good and efficient platform for targeted drug delivery. Imatinib mesylate (IM) was encapsulated in Zn-MOF and IM@Zn-MOF characterized using different technique including X-ray powder diffraction, field emission scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, inductively coupled plasma, Brunauer-Emmett-Teller surface area analysis. The result showed that small molecules of the IM successfully were encapsulated inside of the Zn-MOF. Releasing of drug-loaded Zn-MOF was studied by UV–vis spectroscopy at 240 nm at in vitro condition in HCl (0.1N) and PBS buffer. Rapid release of IM occurs upon hydrolytic decomposition of MOF in dissolution media.