Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid
Kainic acid can simulate excitatory amino acids in vitro. Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to 100 4 000 #M kainic acid for 7 days to induce neuronal cell differentiation, causing the number of astrocytes to be significantly increased. Treatment...
Saved in:
| Published in | Neural regeneration research Vol. 7; no. 12; pp. 891 - 895 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
India
Medknow Publications & Media Pvt. Ltd
25.04.2012
Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China%Department of Urology, the Third People's Hospital of Zhengzhou, Zhengzhou 450051, Henan Province, China%Department of Neurology, the Central Hospital of Nanyang, Nanyang 473009, Henan Province, China Medknow Publications & Media Pvt Ltd |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1673-5374 1876-7958 |
| DOI | 10.3969/j.issn.1673-5374.2012.12.002 |
Cover
| Abstract | Kainic acid can simulate excitatory amino acids in vitro. Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to 100 4 000 #M kainic acid for 7 days to induce neuronal cell differentiation, causing the number of astrocytes to be significantly increased. Treatment with a combination of 0.5 mg/L gastrodin and kainic acid also caused the number of differentiated neurons to be significantly increased compared with treatment with kainic acid alone Experimental findings suggest that gastrodin reduces the excitability of kainic acid and induces neural stem cell differentiation into neurons. |
|---|---|
| AbstractList | Kainic acid can simulate excitatory amino acids in vitro. Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to 100-4 000 μM kainic acid for 7 days to induce neuronal cell differentiation, causing the number of astrocytes to be significantly increased. Treatment with a combination of 0.5 mg/L gastrodin and kainic acid also caused the number of differentiated neurons to be significantly increased compared with treatment with kainic acid alone. Experimental findings suggest that gastrodin reduces the excitability of kainic acid and induces neural stem cell differentiation into neurons. Kainic acid can simulate excitatory amino acids in vitro. Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to 100--4 000 μM kainic acid for 7 days to induce neuronal cell differentiation, causing the number of astrocytes to be significantly increased. Treatment with a combination of 0.5 mg/L gastrodin and kainic acid also caused the number of differentiated neurons to be significantly increased compared with treatment with kainic acid alone. Experimental findings suggest that gastrodin reduces the excitability of kainic acid and induces neural stem cell differentiation into neurons. Abbreviations: GFAP, glial fibrillary acidic protein; NSE, neuron-specific enolase R741; Kainic acid can simulate excitatory amino acids in vitro. Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to 100-4 000 μM kainic acid for 7 days to induce neuronal cell differentiation, causing the number of astrocytes to be significantly increased. Treat-ment with a combination of 0.5 mg/L gastrodin and kainic acid also caused the number of differen-tiated neurons to be significantly increased compared with treatment with kainic acid alone. Ex-perimental findings suggest that gastrodin reduces the excitability of kainic acid and induces neural stem cell differentiation into neurons. Kainic acid can simulate excitatory amino acids in vitro . Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to 100–4 000 μM kainic acid for 7 days to induce neuronal cell differentiation, causing the number of astrocytes to be significantly increased. Treatment with a combination of 0.5 mg/L gastrodin and kainic acid also caused the number of differentiated neurons to be significantly increased compared with treatment with kainic acid alone. Experimental findings suggest that gastrodin reduces the excitability of kainic acid and induces neural stem cell differentiation into neurons. Kainic acid can simulate excitatory amino acids in vitro. Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to 100 4 000 #M kainic acid for 7 days to induce neuronal cell differentiation, causing the number of astrocytes to be significantly increased. Treatment with a combination of 0.5 mg/L gastrodin and kainic acid also caused the number of differentiated neurons to be significantly increased compared with treatment with kainic acid alone Experimental findings suggest that gastrodin reduces the excitability of kainic acid and induces neural stem cell differentiation into neurons. |
| Author | Guifang Sun Zhihao Yuan Boai Zhang Yanjie Jia Yangfei Ji Xingrong Ma Yu Liu Yanru Liu Quanqing Wen Yanling Zhao |
| AuthorAffiliation | Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China Department of Urology, the Third People＇s Hospital of Zhengzhou, Zhengzhou 450051, Henan Province, China Department of Neurology, the Central Hospital of Nanyang, Nanyang 473009, Henan Province, China |
| AuthorAffiliation_xml | – name: Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China%Department of Urology, the Third People's Hospital of Zhengzhou, Zhengzhou 450051, Henan Province, China%Department of Neurology, the Central Hospital of Nanyang, Nanyang 473009, Henan Province, China – name: 1 Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China – name: 2 Department of Urology, the Third People's Hospital of Zhengzhou, Zhengzhou 450051, Henan Province, China – name: 3 Department of Neurology, the Central Hospital of Nanyang, Nanyang 473009, Henan Province, China |
| Author_xml | – sequence: 1 givenname: Guifang surname: Sun fullname: Sun, Guifang organization: Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China – sequence: 2 givenname: Zhihao surname: Yuan fullname: Yuan, Zhihao organization: Department of Urology, the Third People's Hospital of Zhengzhou, Zhengzhou 450051, Henan Province, China – sequence: 3 givenname: Boai surname: Zhang fullname: Zhang, Boai organization: Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China – sequence: 4 givenname: Yanjie surname: Jia fullname: Jia, Yanjie organization: Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China – sequence: 5 givenname: Yangfei surname: Ji fullname: Ji, Yangfei organization: Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China – sequence: 6 givenname: Xingrong surname: Ma fullname: Ma, Xingrong organization: Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China – sequence: 7 givenname: Yu surname: Liu fullname: Liu, Yu organization: Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China – sequence: 8 givenname: Yanru surname: Liu fullname: Liu, Yanru organization: Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China – sequence: 9 givenname: Quanqing surname: Wen fullname: Wen, Quanqing organization: Department of Neurology, the Central Hospital of Nanyang, Nanyang 473009, Henan Province, China – sequence: 10 givenname: Yanling surname: Zhao fullname: Zhao, Yanling organization: Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25722671$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdkU1rFTEUhoNU7If-BYnYhSAz5muSzEaQolUouOnKTcgkmWmmc5N2MqPc_vqey-0tKgQSeB_ePJxzio5STgGhc0pq3sr201jHUlJNpeJVw5WoGaGshkMIe4FOqFayUm2jj-B9YI7RaSkjIY1uGX-FjlmjGJOKnqBfl7Ysc_Yx4W7K7rbgFNbZTrgsYYNdmCbsY9-HOaQl2iXmhGNaMh6mCNAuL3gTPETB426Lb21M0WHron-NXvZ2KuHN032Grr99vb74Xl39vPxx8eWqcryRS8WsEJZ41wkp2s4q5py1RKuuVYJzImQjOuaY7rnqG0oY5aJxlnqrvBDC8zP0eV97t3Zg4kAU_M3dHDd23ppso_k3SfHGDPm3EVxQphkUfNwX_LGpt2kwY17nBMbmYSjjQ9mOJuxmTBlMGOgPT9_N-X4NZTGbWHZzsCnktRgqJYNmQjSg7_9Dn5sZ10wTAmsC6u3f_s_ihx0B8G4PuJuchvsIhgdGUA1My_kjzdSkHw |
| ClassificationCodes | R741 |
| ContentType | Journal Article |
| Copyright | 2012. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © Wanfang Data Co. Ltd. All Rights Reserved. Copyright: © Neural Regeneration Research 2012 |
| Copyright_xml | – notice: 2012. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. – notice: Copyright: © Neural Regeneration Research 2012 |
| DBID | 2RA 92L CQIGP W91 ~WA NPM 3V. 7X7 7XB 88G 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ K9. M0S M2M PHGZM PHGZT PIMPY PKEHL PQEST PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 2B. 4A8 92I 93N PSX TCJ 5PM |
| DOI | 10.3969/j.issn.1673-5374.2012.12.002 |
| DatabaseName | 维普期刊资源整合服务平台 中文科技期刊数据库-CALIS站点 维普中文期刊数据库 中文科技期刊数据库-医药卫生 中文科技期刊数据库- 镜像站点 PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Psychology Database (Alumni) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One ProQuest Central ProQuest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Psychology Database Proquest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) PubMed Central (Full Participant titles) |
| DatabaseTitle | PubMed Publicly Available Content Database ProQuest One Psychology ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Central China ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Central (New) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | PubMed Publicly Available Content Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| DocumentTitleAlternate | Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid |
| EISSN | 1876-7958 |
| EndPage | 895 |
| ExternalDocumentID | PMC4341282 zgsjzsyj_e201212002 25722671 41822693 |
| Genre | Journal Article |
| GeographicLocations | United States--US China |
| GeographicLocations_xml | – name: China – name: United States--US |
| GroupedDBID | --- --K 0R~ 123 1B1 2B. 2C~ 2RA 4.4 53G 5RS 5VR 5VS 7X7 8FI 8FJ 92F 92I 92L 93N 93R AAEDT AAKAS AALRI AAXUO ABUWG ABXLX ACGFS ADBBV ADMUD ADRAZ ADZCM AENEX AFKRA AFUIB ALMA_UNASSIGNED_HOLDINGS AZQEC BAWUL BENPR CCEZO CCPQU CHBEP CIEJG CQIGP CS3 CW9 DIK DU5 DWQXO EBS EJD EMOBN EO8 FA0 FDB FYUFA GNUQQ GROUPED_DOAJ GX1 HMCUK HYE HZ~ IAO IEA IHE IHR IPNFZ ITC KQ8 M2M M41 M48 M5~ NQ- O9- OK1 OVD PIMPY PSYQQ RIG RMW ROL RPM RPZ TCJ TEORI TGQ UKHRP W3E W91 WFFXF ~WA -SE -S~ ADJBI ALIPV CAJEE H13 NPM PGMZT PHGZM PHGZT Q-- U1G U5O 3V. 7XB 8FK K9. PKEHL PQEST PQQKQ PQUKI PRINS PUEGO Q9U 7X8 4A8 ABWVN ACRPL ADNMO PMFND PSX 5PM |
| ID | FETCH-LOGICAL-c356t-2a44a0dcb4649ba72ccaa087b9743304654b2c28f37f51021345ca1da7d444d3 |
| IEDL.DBID | M48 |
| ISSN | 1673-5374 |
| IngestDate | Thu Aug 21 18:25:07 EDT 2025 Thu May 29 04:06:12 EDT 2025 Fri Sep 05 07:52:19 EDT 2025 Sat Aug 23 14:54:55 EDT 2025 Mon Jul 21 05:35:29 EDT 2025 Wed Feb 14 10:46:47 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Keywords | gastrodin differentiation kainic acid neural stem cells |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c356t-2a44a0dcb4649ba72ccaa087b9743304654b2c28f37f51021345ca1da7d444d3 |
| Notes | Kainic acid can simulate excitatory amino acids in vitro. Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to 100 4 000 #M kainic acid for 7 days to induce neuronal cell differentiation, causing the number of astrocytes to be significantly increased. Treatment with a combination of 0.5 mg/L gastrodin and kainic acid also caused the number of differentiated neurons to be significantly increased compared with treatment with kainic acid alone Experimental findings suggest that gastrodin reduces the excitability of kainic acid and induces neural stem cell differentiation into neurons. kainic acid; gastrodin; neural stem cells; differentiation 11-5422/R ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Author contributions: Guifang Sun participated in the study concept and design, as well as manuscript writing. Boai Zhang and Zhihao Yuan were in charge of manuscript authorization. Yanjie Jia and Yanru Liu ensured the integrity of data and participated in manuscript authorization. Yangfei Ji and Xingrong Ma were responsible for statistical analysis. Yu Liu participated in data analysis. Quanqing Wen and Yanling Zhao were responsible for experimentation. Guifang Sun, Master, Attending physician, Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China |
| OpenAccessLink | https://www.proquest.com/docview/2382800958?pq-origsite=%requestingapplication% |
| PMID | 25722671 |
| PQID | 2382800958 |
| PQPubID | 4671210 |
| PageCount | 5 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4341282 wanfang_journals_zgsjzsyj_e201212002 proquest_miscellaneous_1662434008 proquest_journals_2382800958 pubmed_primary_25722671 chongqing_primary_41822693 |
| PublicationCentury | 2000 |
| PublicationDate | 2012-04-25 |
| PublicationDateYYYYMMDD | 2012-04-25 |
| PublicationDate_xml | – month: 04 year: 2012 text: 2012-04-25 day: 25 |
| PublicationDecade | 2010 |
| PublicationPlace | India |
| PublicationPlace_xml | – name: India – name: Mumbai |
| PublicationTitle | Neural regeneration research |
| PublicationTitleAlternate | Neural Regeneration Research |
| PublicationTitle_FL | NEURAL REGENERATION RESEARCH |
| PublicationYear | 2012 |
| Publisher | Medknow Publications & Media Pvt. Ltd Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China%Department of Urology, the Third People's Hospital of Zhengzhou, Zhengzhou 450051, Henan Province, China%Department of Neurology, the Central Hospital of Nanyang, Nanyang 473009, Henan Province, China Medknow Publications & Media Pvt Ltd |
| Publisher_xml | – name: Medknow Publications & Media Pvt. Ltd – name: Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China%Department of Urology, the Third People's Hospital of Zhengzhou, Zhengzhou 450051, Henan Province, China%Department of Neurology, the Central Hospital of Nanyang, Nanyang 473009, Henan Province, China – name: Medknow Publications & Media Pvt Ltd |
| References | 18779056 - Int Rev Cell Mol Biol. 2008;269:1-58 20307513 - Brain Res. 2010 May 21;1332:32-47 19594022 - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Jun;23(6):723-6 18752295 - J Neurosci Res. 2009 Jan;87(1):96-111 19166830 - Dev Biol. 2009 Mar 15;327(2):458-64 17089323 - Planta Med. 2006 Dec;72 (15):1359-65 17304577 - J Neurosci Res. 2007 Sep;85(12 ):2741-55 18981959 - Spine (Phila Pa 1976). 2008 Nov 15;33(24):2596-604 21355215 - Yao Xue Xue Bao. 2010 Apr;45(4):484-8 21231803 - Cytotherapy. 2011 May;13(5):582-93 19275093 - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Feb;23(2):151-5 18053670 - J Pharm Biomed Anal. 2008 Jan 22;46(2):399-404 19029058 - Neuroscientist. 2008 Dec;14(6):544-60 17915045 - Neurol Res. 2008 Apr;30(3):244-50 21697386 - J Neurosci. 2011 Jun 22;31(25):9359-67 19614983 - Eur J Neurosci. 2009 Jul;30(2):175-85 18272152 - Exp Neurol. 2008 Apr;210(2):608-23 20692049 - J Neuroimmunol. 2010 Dec 15;229(1-2):81-90 20137714 - Zhonghua Yi Xue Za Zhi. 2009 Nov 17;89(42):3007-9 16305955 - Di Yi Jun Yi Da Xue Xue Bao. 2005 Nov;25(11):1357-60, 1374 10669485 - J Neurophysiol. 2000 Feb;83(2):693-704 15525765 - J Neurosci. 2004 Nov 3;24(44):9799-810 16998910 - J Neurosci Res. 2006 Nov 15;84(7):1415-24 11507641 - Nature. 2001 Aug 16;412(6848):736-9 |
| References_xml | – reference: 18981959 - Spine (Phila Pa 1976). 2008 Nov 15;33(24):2596-604 – reference: 19275093 - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Feb;23(2):151-5 – reference: 21697386 - J Neurosci. 2011 Jun 22;31(25):9359-67 – reference: 20137714 - Zhonghua Yi Xue Za Zhi. 2009 Nov 17;89(42):3007-9 – reference: 17915045 - Neurol Res. 2008 Apr;30(3):244-50 – reference: 16998910 - J Neurosci Res. 2006 Nov 15;84(7):1415-24 – reference: 10669485 - J Neurophysiol. 2000 Feb;83(2):693-704 – reference: 19166830 - Dev Biol. 2009 Mar 15;327(2):458-64 – reference: 17089323 - Planta Med. 2006 Dec;72 (15):1359-65 – reference: 16305955 - Di Yi Jun Yi Da Xue Xue Bao. 2005 Nov;25(11):1357-60, 1374 – reference: 21231803 - Cytotherapy. 2011 May;13(5):582-93 – reference: 11507641 - Nature. 2001 Aug 16;412(6848):736-9 – reference: 19614983 - Eur J Neurosci. 2009 Jul;30(2):175-85 – reference: 18053670 - J Pharm Biomed Anal. 2008 Jan 22;46(2):399-404 – reference: 20307513 - Brain Res. 2010 May 21;1332:32-47 – reference: 17304577 - J Neurosci Res. 2007 Sep;85(12 ):2741-55 – reference: 18752295 - J Neurosci Res. 2009 Jan;87(1):96-111 – reference: 18272152 - Exp Neurol. 2008 Apr;210(2):608-23 – reference: 19029058 - Neuroscientist. 2008 Dec;14(6):544-60 – reference: 15525765 - J Neurosci. 2004 Nov 3;24(44):9799-810 – reference: 18779056 - Int Rev Cell Mol Biol. 2008;269:1-58 – reference: 19594022 - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Jun;23(6):723-6 – reference: 20692049 - J Neuroimmunol. 2010 Dec 15;229(1-2):81-90 – reference: 21355215 - Yao Xue Xue Bao. 2010 Apr;45(4):484-8 |
| SSID | ssj0058923 |
| Score | 1.8768119 |
| Snippet | Kainic acid can simulate excitatory amino acids in vitro. Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to 100 4 000... Kainic acid can simulate excitatory amino acids in vitro. Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to 100-4 000... Kainic acid can simulate excitatory amino acids in vitro. Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to 100--4... R741; Kainic acid can simulate excitatory amino acids in vitro. Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to... Kainic acid can simulate excitatory amino acids in vitro . Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to 100–4... |
| SourceID | pubmedcentral wanfang proquest pubmed chongqing |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 891 |
| SubjectTerms | Amino acids Antigens Brain research Cell culture Cloning Enzymes Fibroblasts Growth factors Hazardous materials Laboratory animals Nervous system Neurons Research and Report: Traditional Chinese Medicine and Neuroregeneration Stem cells Tumor necrosis factor-TNF 介导 兴奋性氨基酸 天麻素 神经干细胞 神经胶质细胞 红藻氨酸 细胞分化 细胞治疗 |
| SummonAdditionalLinks | – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB5BEY9LBZRH2oKMtOIWuvEzOaEKUSokOBVpxSXyI7vstvW2JBXa_npmvNmUCsR5HMvxjOfl8XwAoyoZGV7lnpsxBSjU8ta7XJpGOV-WTif4ti9f9fE3-XmiJn3Cre3LKjc6MSnqsPSUIz9A08JLcgjK9xeXOaFG0e1qD6FxF-6l1mUoz2YyBFyqrBK8W6GNyJUw8gGMKEqtdHWwSGfs3UCiIi-eEoOUYHmIqifOLtF4_Mvx_Lt-8v4vG6c2zv4wTUePYbv3KdnhWgiewJ0mPoWdw4jx9PmKvWWpyjOlz3fg-yfbdqg055E5tGOnLaOOlvg1NXRmlMZnG8yUbs01No_dks3OUFATvWXptQl6qsyt2CkhTHhm_Tw8g5OjjycfjvMeXyH3Quku51ZKOw7eSS0rZw1HbtpxaRzGGJTm0Eo67nk5FWaqCAJcSOVtEawJUsognsNWXMbmJTCrgmyEDarRXlpXVtYQ74ULvmjC2GawO-xofbFuo1FLDG24rkQG-5strvsD1NY37M7gzUBG0acftbFZXrV1oTWXApUQjnmx5sgwOWoinNwUGZhbvBoGUFvt25Q4_5Haa-OUaLR5BqOeqzerup61i-t2tagbEpeCClx2_7_6PXhEQ-n-iat92Op-XjWv0I3p3Oskq78B8zTxaQ priority: 102 providerName: ProQuest |
| Title | Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid |
| URI | http://lib.cqvip.com/qk/88507X/201212/41822693.html https://www.ncbi.nlm.nih.gov/pubmed/25722671 https://www.proquest.com/docview/2382800958 https://www.proquest.com/docview/1662434008 https://d.wanfangdata.com.cn/periodical/zgsjzsyj-e201212002 https://pubmed.ncbi.nlm.nih.gov/PMC4341282 |
| Volume | 7 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwED-NTSBeEDAYHaMyUsVbRuPP5AGhgTompE0IbaLiJbKdtGs3XLZkgu6v585tAxN72EsUyfYp9p19H778DqCXRyXD88Rz0ycHhSBvvUukqZTzWeZ0LN92eKQPTuTnoRquwSqtebmA9a2uHdWTOrk83_19MX-PG_4deZy5zt9O437ZTbURiRKGIiUpj0E-QpncQB2lyS07lO39gsryWPitHfIAenehRgAMp7MwvkC1cptJ-n9m5f1fNoxsGP-jtPYfw6Oltcn2FuLxBNaq8BQ29wJ62j_m7A2L-Z8xsL4J3z_ZusHjdBKYQw13VjPCusTRBPXMKMDPVtVUmgU_2SQ0MzY-RxGO7TWL_6GgDcvcnJ1R7QnPrJ-Uz-B4f3D88SBZVl5IvFC6SbiV0vZL76SWubOGI59tPzMOvQ8KgGglHfc8GwkzUlQcXEjlbVpaU0opS_Ec1sMsVC-AWVXKSthSVdpL67LcGpIK4UqfVmXfdmC7XdHi5wJgo5Do9HCdiw7srJa4WElGgTYGz8gyzDrwum3GTUETtaGaXdVFqjWXAo8n7LO14EhLHM8oJG7SDpgbvGo7EOD2zZYwOY3A20gS1TnvQG_J1b9fdT2up9f1fFpUJC4ppb5s363bS3hI73RDxdUOrDeXV9UrNHQa14V7Zmi6sPFhcPTlazeGC7pRjvH5TQz-AHvv_0g |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3LbhMxcFRSQbkgoDxSChgpcFua9fqxe0CoQEtK2wihIlW9rGzvJiQFp2W3qtJ_4h-ZcbIpFYhbz2OPbM_bHs8AdLJgZHgWOa67FKBQyVtnI6FLaV2aWhXat-33Ve-r-HQoD5fgV_MXhtIqG50YFHUxcXRHvoGmhafkEKRvT04j6hpFr6tNC40ZW-yW03MM2ao3Ox-Qvi853946eN-L5l0FIpdIVUfcCGG6hbNCicwazXEPpptqi541BfdKCssdTweJHkhqfJ0I6UxcGF0IIYoE0d6AZUEfWluw_G6r__lLo_plmoV-crHSSSQTLW5Bh8LiTGUb4yDUrxcgyirj4SaSbnRWUNf54Slaq395un8nbN48N35g_PAPW7h9F-7MnVi2OeO6e7BU-vuwuukxgP8xZa9YSCsN9_WrcPTRVDVq6ZFnFg3nccWohCbOpgrSjN4NWNOkpZ6xCRv5esKG31EyArxi4XsLusbMTtkxtbRwzLhR8QAOruPoH0LLT3z5GJiRhSgTU8hSOWFsmhlNzJbYwsVl0TVtWFucaH4yq9uRC4yluMqSNqw3R5zPJbbKL_mrDS8WYJQ12qjx5eSsymOluEhQ6-GYRzOKLJCj6kPkOm6DvkKrxQCq430V4kffQj1vRIleAm9DZ07Vy1VdDKvxRTUd5yWxS0wZNWv_X_1zWOkd7O_lezv93Sdwm6bR4xeX69Cqf56VT9GHqu2zOecyyK9ZVn4DwE0uIw |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3LbhMxcFSKKFwQUB4pBYwUuC3J-rl7QKiihJZCxaFIFZeV7d2EpOC07FZV-mf8HTNOsqUCcet57JHtedvjGYBuHo0MzxPPTZ8CFCp5610iTaWczzKnY_u2T_t654v8cKgOV-DX8i8MpVUudWJU1OXU0x15D00Lz8ghyHrDRVrE5-3Bm-OThDpI0Uvrsp3GnEX2qtkZhm_1691tpPULzgfvDt7uJIsOA4kXSjcJt1Lafumd1DJ31nDcj-1nxqGXTYG-VtJxz7OhMENFTbCFVN6mpTWllLIUiPYaXDcCnSoUJXPYxnoqy2NnuVQbkShh5Bp0KUDOdd6bRPF-1YIov4zHO0m627mJWi-MTtBu_cvn_Tt188aZDUMbRn9YxcEduL1wZ9nWnP_uwkoV7sH6VsBQ_seMvWQxwTTe3K_D1_e2blBfjwNzaEKPakbFNHE21ZJm9ILAlu1amjnDsHFopmz0HWUkwmsWP7qgk8zcjB1RcwvPrB-X9-HgKg7-AayGaageAbOqlJWwpaq0l9ZluTXEdsKVPq3Kvu3ARnuixfG8gkchMariOhcd2FwecbGQ3bq44LQOPG_BKHW0URuq6WldpFpzKVD_4ZiHc4q0yFEJInKTdsBcolU7gCp6X4aE8bdY2RtRor_AO9BdUPViVeejenJezyZFReySUm7Nxv9X_wzWUEKKj7v7e4_hFs2iVzCuNmG1-XlaPUFnqnFPI9syKK5YTH4DYoAw6g |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Gastrodin+blocks+neural+stem+cell+differentiation+into+glial+cells+mediated+by+kainic+acid&rft.jtitle=%E4%B8%AD%E5%9B%BD%E7%A5%9E%E7%BB%8F%E5%86%8D%E7%94%9F%E7%A0%94%E7%A9%B6%EF%BC%88%E8%8B%B1%E6%96%87%E7%89%88%EF%BC%89&rft.au=Guifang+Sun&rft.au=Zhihao+Yuan&rft.au=Boai+Zhang&rft.au=Yanjie+Jia&rft.date=2012-04-25&rft.pub=Department+of+Neurology%2C+the+First+Affiliated+Hospital%2C+Zhengzhou+University%2C+Zhengzhou+450052%2C+Henan+Province%2C+China%25Department+of+Urology%2C+the+Third+People%27s+Hospital+of+Zhengzhou%2C+Zhengzhou+450051%2C+Henan+Province%2C+China%25Department+of+Neurology%2C+the+Central+Hospital+of+Nanyang%2C+Nanyang+473009%2C+Henan+Province%2C+China&rft.issn=1673-5374&rft.volume=7&rft.issue=12&rft.spage=891&rft.epage=895&rft_id=info:doi/10.3969%2Fj.issn.1673-5374.2012.12.002&rft.externalDocID=zgsjzsyj_e201212002 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F88507X%2F88507X.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fzgsjzsyj-e%2Fzgsjzsyj-e.jpg |