Gene polymorphisms are associated with clinical outcome in Chinese resected laryngeal carcinoma patients

• Published in: Oncotarget Vol. 7; no. 44; pp. 71703 - 71709
• Main Authors: Chen, Peng, Chen, Zhengshuai, Li, Jinglie, Yang, Hua, Zhu, Yuanyuan, Zhang, Ning, Yan, Mengdan, Shao, Yuan, Chen, Chao, Jin, Tianbo
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 01.11.2016
• Subjects: Adult; Aged; Aged, 80 and over; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Genotype; Humans; Laryngeal Neoplasms - genetics; Laryngeal Neoplasms - mortality; Middle Aged; Polymorphism, Single Nucleotide; Prognosis; Proportional Hazards Models; Research Paper; Ubiquitin-Protein Ligases - genetics; overall survival; prognostic marker; single-nucleotide polymorphism; laryngeal carcinoma; prognosis
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.12323

We examined the multigenetic index on the progression of laryngeal carcinoma in Chinese population. This study aims to assess the effects of single nucleotide polymorphisms (SNPs) on survival of Laryngeal Carcinoma (LC) patients. Eighteen SNPs were selected and genotyped using the Sequenom iPLEX genotyping system in a cohort of 170 resected Chinese LC patients. Multivariate Cox proportional hazards model and Kaplan-Meier curve were used for the prognosis analysis. Overall, the median survival time (MST) was 38.00 months. The one, three and five year Kaplan-Meier survival rate was 0.847 ± 0.028, 0.572 ± 0.038 and 0.471 ± 0.041 respectively. The risks of death with the Hazard Ratio (HR) [95% confidence intervals] (CI) of 2.40 (1.15-4.50), 2.17 (1.45-3.25), 2.39 (1.58-3.62), 3.29 (2.10-5.18), respectively. There was significant associations between the SNPs and OS when the entire study population was examined. The rs1321311 TG genotype (vs.GG), rs2494938 AA genotype (vs. GG) and rs9363918 TG genotype (vs. GG) were associated with a worse prognosis for OS (adjusted HR = 1.64; 95%confidence interval = 1.07-2.51; P = 0.022, adjusted HR = 2.85; P =0.12; adjusted HR = 1.78; P = 0.009; respectively).The results suggest for the first time that these gene polymorphisms may serve as an independent prognostic marker for LC patients.