Circadian Biology and the Neurovascular Unit

Mammalian physiology and cellular function are subject to significant oscillations over the course of every 24-hour day. It is likely that these daily rhythms will affect function as well as mechanisms of disease in the central nervous system. In this review, we attempt to survey and synthesize emer...

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Bibliographic Details
Published inCirculation research Vol. 134; no. 6; pp. 748 - 769
Main Authors Li, Wenlu, Tiedt, Steffen, Lawrence, Jennifer H, Harrington, Mary E, Musiek, Erik S, Lo, Eng H
Format Journal Article
LanguageEnglish
Published United States 15.03.2024
Subjects
aging
cerebrovascular disorders
stroke
circadian clocks
central nervous system
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Summary:Mammalian physiology and cellular function are subject to significant oscillations over the course of every 24-hour day. It is likely that these daily rhythms will affect function as well as mechanisms of disease in the central nervous system. In this review, we attempt to survey and synthesize emerging studies that investigate how circadian biology may influence the neurovascular unit. We examine how circadian clocks may operate in neural, glial, and vascular compartments, review how circadian mechanisms regulate cell-cell signaling, assess interactions with aging and vascular comorbidities, and finally ask whether and how circadian effects and disruptions in rhythms may influence the risk and progression of pathophysiology in cerebrovascular disease. Overcoming identified challenges and leveraging opportunities for future research might support the development of novel circadian-based treatments for stroke.
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ISSN:0009-7330
1524-4571
DOI:10.1161/CIRCRESAHA.124.323514