Surface Modification of T-Lymphocytes Observed during Rosetting

Scanning electron microscopy has been used to characterize alterations of lymphocyte surface topology that occur on contact with erythrocytes during the rosetting reaction. Molt-4 cells, a line of leukemic human lymphocytes, defined as T-cells through their ability to form rosettes with sheep erythr...

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Published inScience (American Association for the Advancement of Science) Vol. 184; no. 4143; pp. 1300 - 1301
Main Authors Lin, Peck-Sun, Donald F. Hoelzl Wallach
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 21.06.1974
Subjects
Animals
Antigens
B lymphocytes
Cell Line
Cell Membrane - immunology
Clone Cells
Erythrocytes
Erythrocytes - immunology
Genetic loci
Humans
Immune Adherence Reaction
Leukemia
Lymphocytes
Mathematical surfaces
Microscopy, Electron, Scanning
Microvilli
Pseudopodia
Sheep - immunology
T lymphocytes
T-Lymphocytes - cytology
T-Lymphocytes - immunology
Thymocytes
Topology
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Summary:Scanning electron microscopy has been used to characterize alterations of lymphocyte surface topology that occur on contact with erythrocytes during the rosetting reaction. Molt-4 cells, a line of leukemic human lymphocytes, defined as T-cells through their ability to form rosettes with sheep erythrocytes, were used for this. Unreacted Molt-4 cells exhibit surfaces that are virtually smooth and carry few microvilli. In contrast, Molt-4 cells in rosettes display a time-dependent modification of surface topology, characterized by the emergence of numerous, long microvilli, particularly in areas of red cell contact.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0036-8075
1095-9203
DOI:10.1126/science.184.4143.1300