Extracellular vesicles in food: Experimental evidence of their secretion in grape fruits

In the last decade, the number of studies related with extracellular vesicles (EVs) has dramatically grown since their role as key part of intercellular communication has been confirmed. EVs, as transporter of distinct bioactive molecules, can take part in different physiological mechanisms and have...

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Published inEuropean journal of pharmaceutical sciences Vol. 98; pp. 40 - 50
Main Authors Pérez-Bermúdez, Pedro, Blesa, Jesús, Soriano, José Miguel, Marcilla, Antonio
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.02.2017
Subjects
Animals
Extracellular vesicles
Extracellular Vesicles - secretion
Food exosomes
Fruit - metabolism
Fruit and Vegetable Juices - analysis
Grape berry
Humans
Milk - chemistry
Plant Proteins - analysis
Plant Proteins - metabolism
Proteomics
Secretion
Vitis - metabolism
Vitis vinifera
Extracellular vesicles
Grape berry
Food exosomes
Secretion
Vitis vinifera
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Summary:In the last decade, the number of studies related with extracellular vesicles (EVs) has dramatically grown since their role as key part of intercellular communication has been confirmed. EVs, as transporter of distinct bioactive molecules, can take part in different physiological mechanisms and have been gaining attention as potential tools with a wide range of therapeutic effects. Whereas a high number of studies have been published related to mammalian derived EVs, including products as food source, the existence of EVs in plants still is controversial. Recent descriptions of vesicles derived from edible plants show that they might contain pharmacological active molecules. In this context, EVs from food are attracting increasing interest due to their relevance in modulating cellular processes (involved in health and disease), as well as therapeutic vehicles. The present work aims to summarize the current knowledge on exosomes in foods, actually limited to only four FAO groups (Milk, Starchy roots and tubers, Nuts and seeds, and Fruits). In addition, we have further characterized EVs isolated from grape berry juice by classical differential centrifugation, and described a preliminary dissection of their secretion in vivo. [Display omitted]
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ISSN:0928-0987
1879-0720
DOI:10.1016/j.ejps.2016.09.022