Testosterone-estradiol-binding globulin in patients with Turner's syndrome: effects of estrogens and acute growth hormone administration

The TeBG activity of plasma from patients with Turner's syndrome was measured quantitatively using polyacrylamide gel electrophoresis. Human growth hormone administration did not significantly change the plasma TeBG levels. However, oral replacement therapy with estrogens elevated plasma TeBG w...

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Bibliographic Details
Published inThe journal of clinical endocrinology and metabolism Vol. 42; no. 6; p. 1018
Main Authors Bergink, E W, Wolf, D L, Wittliff, J L, Bruining, G J, Bryson, M F, Forbes, G B
Format Journal Article
LanguageEnglish
Published United States 01.06.1976
Subjects
Adolescent
Age Determination by Skeleton
Child
Estradiol - blood
Estrogens, Conjugated (USP) - therapeutic use
Ethinyl Estradiol - therapeutic use
Growth Hormone - therapeutic use
Humans
Protein Binding
Serum Globulins - metabolism
Testosterone - blood
Turner Syndrome - blood
Turner Syndrome - drug therapy
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Summary:The TeBG activity of plasma from patients with Turner's syndrome was measured quantitatively using polyacrylamide gel electrophoresis. Human growth hormone administration did not significantly change the plasma TeBG levels. However, oral replacement therapy with estrogens elevated plasma TeBG within 3 days; after 9 days these levels reached a maximum of three- to four-fold greater than that observed at a time prior to therapy.
ISSN:0021-972X
DOI:10.1210/jcem-42-6-1018