Evaluation of emotional reactions to oral contraceptive use

A review of available clinical studies indicates that 10 to 40 per cent of oral contraceptive users may suffer mild to moderate depression syndromes. Clinical and animal data indicate that a variety of mechanisms may be involved, including alterations in folate, pyridoxine, and vitamine B12 metaboli...

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Bibliographic Details
Published inAmerican journal of obstetrics and gynecology Vol. 126; no. 8; p. 968
Main Author Kane, Jr, F J
Format Journal Article
LanguageEnglish
Published United States 15.12.1976
Subjects
Ascorbic Acid - metabolism
Biogenic Amines - metabolism
Clinical Trials as Topic
Contraceptives, Oral - adverse effects
Contraceptives, Oral - pharmacology
Depression - chemically induced
Dose-Response Relationship, Drug
Emotions - drug effects
Estrogens - adverse effects
Female
Folic Acid - metabolism
Humans
Male
Progestins - adverse effects
Pyridoxine - metabolism
Sexual Dysfunction, Physiological - chemically induced
Time Factors
Vitamin A - metabolism
Vitamin B 6 Deficiency - chemically induced
Decreased Libido
Central Nervous System Effects
Oral Contraceptives > side effects
Depression
Psychological Factors
Biology
Contraception
Contraceptive Methods > side effects
Family Planning
Vitamins
Diseases
Literature Review
Mental Disorders
Vitamin B Complex
Physiology
Behavior
Sex Behavior
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Summary:A review of available clinical studies indicates that 10 to 40 per cent of oral contraceptive users may suffer mild to moderate depression syndromes. Clinical and animal data indicate that a variety of mechanisms may be involved, including alterations in folate, pyridoxine, and vitamine B12 metabolism, as well as related effects on biogenic amine metabolism. Interactive effects may result, such as impairment of usual coping mechnisms and psychological defenses by altered central nervous system function.
ISSN:0002-9378
DOI:10.1016/0002-9378(76)90686-4