Primary idiopathic CNS non-amyloidogenic light chain deposition disease complicated by treatment-resistant focal seizure disorder

•LCDD is disorder involving deposition of immunoglobulin light chains.•CNS-restricted LCDD is among the rarest manifestations.•This unique case is complicated focal onset epilepsy with for which therapy proved difficult. Light chain deposition disease (LCDD) is a systemic disorder characterised by t...

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Published inJournal of clinical neuroscience Vol. 59; pp. 313 - 315
Main Authors Grainger, Brian T., Issa, Samar, Anderson, Neil E.
Format Journal Article
LanguageEnglish
Published Scotland Elsevier Ltd 01.01.2019
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Summary:•LCDD is disorder involving deposition of immunoglobulin light chains.•CNS-restricted LCDD is among the rarest manifestations.•This unique case is complicated focal onset epilepsy with for which therapy proved difficult. Light chain deposition disease (LCDD) is a systemic disorder characterised by the pathologic deposition of immunoglobulin light chains, which is histologically distinguished from amyloidosis by failure to stain with Congo red. Central nervous system (CNS)-restricted LCDD is among the rarest manifestations. We describe a unique case complicated by focal onset epilepsy with impaired awareness for which control with anticonvulsant therapy proved difficult.
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ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2018.10.123