Human Serum Albumin as Multifunctional Nanocarrier for Cancer Therapy

• Published in: Journal of pharmaceutical sciences Vol. 110; no. 9; pp. 3111 - 3117
• Main Authors: Zeeshan, Farrukh, Madheswaran, Thiagarajan, Panneerselvam, Jithendra, Taliyan, Rajeev, Kesharwani, Prashant
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2021
• Subjects: Drug delivery; Human serum albumin Albumin-based nanocarriers (ANCs); Nanomedicine; Nanoparticle; Targeted drug delivery; Toxicity; Targeted drug delivery; Drug delivery; Nanoparticle; Toxicity; Nanomedicine; Human serum albumin Albumin-based nanocarriers (ANCs); toxicity; Human serum albumin; albumin-based nanocarriers (ANCs); nanomedicine; nanoparticle; targeted drug delivery; drug delivery
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1016/j.xphs.2021.05.001

Human serum albumin or simply called albumin is a flexible protein employed as a carrier in the fabrication of albumin-based nanocarriers (ANCs) for the administration of cancer therapeutics. Albumin can contribute enhanced tumour specificity, reduced drug induced cytotoxicity and retain concentration of the therapeutically active agent such as drug, peptide, protein, and gene for a prolonged time duration. Nevertheless, apart from cancer management, ANCs are also employed in the diagnosis, imaging, and multimodal cancer therapy. This article figures out salient characteristics, design as well as categories of ANCs in the context of their application in cancer management. In addition, this review article discusses the fabrication methods of ANCs, use of ANCs in gene, cancer, and multimodal therapy along with cancer diagnosis and imaging. Lastly, this review also briefly discusses about (ANCs) formulations, commercial products, and those under clinical testing.