Plasma levels of norethisterone measured by radioimmunoassay and gas chromatography-mass fragmentography

The concentration of norethisterone in plasma samples from subjects receiving I mg of the steroid orally was measured by radioimmunoassay without chromatography and by gas chromatography-mass fragmentography (g.c.-m.f.). Although values obtained by radioimmunoassay were usually higher than those obt...

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Bibliographic Details
Published inJournal of steroid biochemistry Vol. 10; no. 1; pp. 121 - 122
Main Authors Fotherby, K., Warren, R.J., Shrimanker, K., Siekmann, L., Siekmann, Anita, Breuer, H.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 1979
Subjects
Administration, Oral
Chromatography, Gas
Gas Chromatography-Mass Spectrometry
Humans
Norethindrone - administration & dosage
Norethindrone - blood
Norethindrone - pharmacology
Population
Radioimmunoassay
Prospective Studies
Laboratory Examinations And Diagnoses
Contraception
Laboratory Procedures
Family Planning
Research Methodology
Examinations And Diagnoses
Contraceptive Agents, Progestin > analysis
Studies
Contraceptive Methods
Contraceptive Agents, Female > analysis
Contraceptive Agents > analysis
Oral Contraceptives
Norethindrone > analysis
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Summary:The concentration of norethisterone in plasma samples from subjects receiving I mg of the steroid orally was measured by radioimmunoassay without chromatography and by gas chromatography-mass fragmentography (g.c.-m.f.). Although values obtained by radioimmunoassay were usually higher than those obtained by m.f. the correlation coefficient for the two sets of results was 0.96. For concentrations of norethisterone above 500 pg/ml the mean over-estimate by radioimmunoassay was less than 30%.
Bibliography:ObjectType-Article-1
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ISSN:0022-4731
DOI:10.1016/0022-4731(79)90152-3