Reduction of Recombinant Adeno-Associated Virus Vector Adsorption on Solid Surfaces by Polyionic Hydrophilic Complex Coating
Recombinant adeno-associated virus (rAAV) vectors have proven efficacy as gene therapy vehicles. However, non-specific adsorption of these vectors on solid surfaces is encountered during production, storage, and administration, as well as in quantification processes. Such adsorption has been reporte...
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| Published in | Journal of pharmaceutical sciences Vol. 111; no. 3; pp. 663 - 671 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Elsevier Inc
01.03.2022
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| Abstract | Recombinant adeno-associated virus (rAAV) vectors have proven efficacy as gene therapy vehicles. However, non-specific adsorption of these vectors on solid surfaces is encountered during production, storage, and administration, as well as in quantification processes. Such adsorption has been reported to result in the loss of up to 90% of vector particles and can also result in high variability in vector genome quantification. In this study, we demonstrate the effective decrease of recombinant adeno-associated virus vector adsorption by application of a polyionic hydrophilic complex polymer coating on the surfaces of the tools used in viral vector quantification analyses [i.e., pipette tips, cryotube vials, and quantitative polymerase chain reaction (qPCR) plates]. qPCR analyses showed efficient recovery of vector particles from tools with this coating, with up to 95% of vector particle loss being prevented, leading to a higher transduction efficiency in vitro. Thus, the tested coating has the potential to be widely used in material processing in the gene therapy field. |
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| AbstractList | Recombinant adeno-associated virus (rAAV) vectors have proven efficacy as gene therapy vehicles. However, non-specific adsorption of these vectors on solid surfaces is encountered during production, storage, and administration, as well as in quantification processes. Such adsorption has been reported to result in the loss of up to 90% of vector particles and can also result in high variability in vector genome quantification. In this study, we demonstrate the effective decrease of recombinant adeno-associated virus vector adsorption by application of a polyionic hydrophilic complex polymer coating on the surfaces of the tools used in viral vector quantification analyses [i.e., pipette tips, cryotube vials, and quantitative polymerase chain reaction (qPCR) plates]. qPCR analyses showed efficient recovery of vector particles from tools with this coating, with up to 95% of vector particle loss being prevented, leading to a higher transduction efficiency in vitro. Thus, the tested coating has the potential to be widely used in material processing in the gene therapy field. |
| Author | Hiroi, Yoshiomi Ramy, Salama Torisu, Tetsuo Hiroi, Miya Ueda, Yuki Uchiyama, Susumu Nakajima, Hiroyuki |
| Author_xml | – sequence: 1 givenname: Salama orcidid: 0000-0002-6352-9353 surname: Ramy fullname: Ramy, Salama organization: Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan – sequence: 2 givenname: Yuki surname: Ueda fullname: Ueda, Yuki organization: Nissan Chemical Corporation, Tokyo, Japan – sequence: 3 givenname: Hiroyuki surname: Nakajima fullname: Nakajima, Hiroyuki organization: Nissan Chemical Corporation, Tokyo, Japan – sequence: 4 givenname: Miya surname: Hiroi fullname: Hiroi, Miya organization: Nissan Chemical Corporation, Tokyo, Japan – sequence: 5 givenname: Yoshiomi surname: Hiroi fullname: Hiroi, Yoshiomi organization: Nissan Chemical Corporation, Tokyo, Japan – sequence: 6 givenname: Tetsuo orcidid: 0000-0002-8269-7803 surname: Torisu fullname: Torisu, Tetsuo organization: Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan – sequence: 7 givenname: Susumu orcidid: 0000-0002-5181-179X surname: Uchiyama fullname: Uchiyama, Susumu email: suchi@bio.eng.osaka-u.ac.jp organization: Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34706282$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1021_jasms_2c00087 crossref_primary_10_1016_j_tibtech_2023_04_002 crossref_primary_10_1016_j_trac_2023_117088 crossref_primary_10_1039_D3AY01560B crossref_primary_10_1016_j_ejpb_2023_07_002 crossref_primary_10_1016_j_cis_2023_103006 |
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| Keywords | Adeno-associated virus (AAV) PBS FDA Viral vector COP Polymer PHC Contact angle Surfactant D-PBS (–) rAAV GFP ddPCR VG Surface binding RSS Adsorption F/T cycles AAV qPCR Coating zwitterion Gene therapy |
| Language | English |
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