Which is a real valuable screening tool for lung cancer and measure thoracic diseases, chest radiography or low-dose computed tomography?: A review on the current status of Japan and other countries

• Published in: Medicine (Baltimore) Vol. 103; no. 19; p. e38161
• Main Authors: Kasuga, Ikuma, Yokoe, Yoshimi, Gamo, Sanae, Sugiyama, Tomoko, Tokura, Michiyo, Noguchi, Maiko, Okayama, Mayumi, Nagakura, Rei, Ohmori, Nariko, Tsuchiya, Takayoshi, Sofuni, Atsushi, Itoi, Takao, Ohtsubo, Osamu
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 10.05.2024
• Subjects: Early Detection of Cancer - methods; Humans; Japan - epidemiology; Lung Neoplasms - diagnostic imaging; Mass Screening - methods; Narrative Review; Pulmonary Disease, Chronic Obstructive - diagnostic imaging; Radiation Dosage; Radiography, Thoracic - methods; Thoracic Diseases - diagnostic imaging; Tomography, X-Ray Computed - methods; Japan
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000038161

Chest radiography (CR) has been used as a screening tool for lung cancer and the use of low-dose computed tomography (LDCT) is not recommended in Japan. We need to reconsider whether CR really contributes to the early detection of lung cancer. In addition, we have not well discussed about other major thoracic disease detection by CR and LDCT compared with lung cancer despite of its high frequency. We review the usefulness of CR and LDCT as veridical screening tools for lung cancer and other thoracic diseases. In the case of lung cancer, many studies showed that LDCT has capability of early detection and improving outcomes compared with CR. Recent large randomized trial also supports former results. In the case of chronic obstructive pulmonary disease (COPD), LDCT contributes to early detection and leads to the implementation of smoking cessation treatments. In the case of pulmonary infections, LDCT can reveal tiny inflammatory changes that are not observed on CR, though many of these cases improve spontaneously. Therefore, LDCT screening for pulmonary infections may be less useful. CR screening is more suitable for the detection of pulmonary infections. In the case of cardiovascular disease (CVD), CR may be a better screening tool for detecting cardiomegaly, whereas LDCT may be a more useful tool for detecting vascular changes. Therefore, the current status of thoracic disease screening is that LDCT may be a better screening tool for detecting lung cancer, COPD, and vascular changes. CR may be a suitable screening tool for pulmonary infections and cardiomegaly.