Gauging circadian variation in ketamine metabolism by real-time breath analysis

The time-of-day of drug application is an important factor in maximizing efficacy and minimizing toxicity. Real-time in vivo mass spectrometric breath analysis of mice was deployed to investigate time-of-day variation in ketamine metabolism. Different production rates of ketamine metabolites, includ...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 53; no. 14; pp. 2264 - 2267
Main Authors Martinez-Lozano Sinues, P, Kohler, M, Brown, S A, Zenobi, R, Dallmann, R
Format Journal Article
LanguageEnglish
Published England 14.02.2017
Subjects
Drugs
Effectiveness
Gauging
In vivo methods and tests
Metabolism
Phases
Real time
Toxicity
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Summary:The time-of-day of drug application is an important factor in maximizing efficacy and minimizing toxicity. Real-time in vivo mass spectrometric breath analysis of mice was deployed to investigate time-of-day variation in ketamine metabolism. Different production rates of ketamine metabolites, including the recently described anti-depressant hydroxynorketamine, were found in opposite circadian phases. Thus, breath analysis has potential as a rapid and 3Rs (Replacement, Reduction and Refinement) conforming screening method to estimate the time-dependence of drug metabolism.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc09061c