Posttranslational protein modifications: new flavors in the menu of autoantigens

Perhaps one of the most elusive areas of study in autoimmunity has been identifying the self-antigens that initially trigger the development of autoimmune responses. Recent work in this area has demonstrated that a number of biochemical modifications that arise in proteins after their translation in...

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Bibliographic Details
Published inCurrent opinion in rheumatology Vol. 14; no. 3; p. 244
Main Authors Doyle, Hester A, Mamula, Mark J
Format Journal Article
LanguageEnglish
Published United States 01.05.2002
Subjects
Amino Acids - genetics
Autoantigens - genetics
Autoimmune Diseases - diagnosis
Autoimmune Diseases - therapy
Humans
Immune Tolerance
Protein Processing, Post-Translational
Proteins - genetics
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Summary:Perhaps one of the most elusive areas of study in autoimmunity has been identifying the self-antigens that initially trigger the development of autoimmune responses. Recent work in this area has demonstrated that a number of biochemical modifications that arise in proteins after their translation induce autoimmune responses to otherwise ignored self-proteins. This article will describe those autoimmune diseases in which posttranslational modifications may play a role in initiation of disease, as well as identify how these modifications arise and contribute to the breakdown of immune tolerance. Lastly, we will address how posttranslational modifications in self-antigens affect current diagnostic techniques and the development of immunotherapies for autoimmune diseases.
ISSN:1040-8711
1531-6963
DOI:10.1097/00002281-200205000-00009