Managing Recurring Obstetric Cholestasis With Metformin

BACKGROUND:Obstetric cholestasis is a pregnancy-related disorder associated with an adverse pregnancy outcome. It is characterized by generalized pruritus, elevated bile acids, and abnormal liver enzymes. Recent publications show that obstetric cholestasis is associated with, and likely to potentiat...

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Published inObstetrics and gynecology (New York. 1953) Vol. 128; no. 6; pp. 1320 - 1323
Main Authors Elfituri, Abdullatif, Ali, Amanda, Shehata, Hassan
Format Journal Article
LanguageEnglish
Published United States by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved 01.12.2016
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Summary:BACKGROUND:Obstetric cholestasis is a pregnancy-related disorder associated with an adverse pregnancy outcome. It is characterized by generalized pruritus, elevated bile acids, and abnormal liver enzymes. Recent publications show that obstetric cholestasis is associated with, and likely to potentiate, the risk of developing gestational diabetes mellitus. CASE:This case describes an unusual pattern of the disease, in which obstetric cholestasis occurred in five consecutive pregnancies with a different course of the disease in the fifth pregnancy. CONCLUSION:A patient with recurrent cholestasis of pregnancy had worsening disease in her first four pregnancies. In her fifth pregnancy, treatment for gestational diabetes mellitus with metformin was associated with a lowering effect on bile acids and liver enzymes, indicating a possible role for metformin in the management of obstetric cholestasis.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0029-7844
1873-233X
DOI:10.1097/AOG.0000000000001748