Delayed Norfentanyl Clearance During Pregnancy
BACKGROUND:We report a case of delayed norfentanyl clearance in a 33-year-old pregnant woman. Norfentanyl is the major metabolite of fentanyl. CASE:A multigravid woman with opioid use disorder presented at 7 weeks of gestation for treatment. Despite opioid abstinence, her urine was positive for norf...
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Published in | Obstetrics and gynecology (New York. 1953) Vol. 136; no. 5; pp. 905 - 907 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved
01.11.2020
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Subjects | |
Online Access | Get full text |
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Summary: | BACKGROUND:We report a case of delayed norfentanyl clearance in a 33-year-old pregnant woman. Norfentanyl is the major metabolite of fentanyl.
CASE:A multigravid woman with opioid use disorder presented at 7 weeks of gestation for treatment. Despite opioid abstinence, her urine was positive for norfentanyl on 10 distinct gas chromatography–mass spectrometry urine screens. The results demonstrated a steady decrease of norfentanyl over the course of 70 days after her last fentanyl usage, far exceeding expected rates of fentanyl clearance.
CONCLUSION:This case highlights the importance of acknowledging pregnancy, genetic, or medication-induced changes to fentanyl pharmacokinetics when interpreting urine tests, especially given the potential sequelae of a false-positive urine test result. |
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ISSN: | 0029-7844 1873-233X |
DOI: | 10.1097/AOG.0000000000004106 |