Advancement and prospects of tumor gene therapy

Gene therapy is one of the most attractive fields in tumor therapy. In past decades, significant progress has been achieved. Various approaches, such as viral and non-viral vectors and physical methods, have been developed to make gene delivery safer and more efficient. Several therapeutic strategie...

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Published inAi zheng Vol. 30; no. 3; pp. 182 - 188
Main Authors Zhang, Chao, Wang, Qing-Tao, Liu, He, Zhang, Zhen-Zhu, Huang, Wen-Lin
Format Journal Article
LanguageChinese
English
Published England State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China 01.03.2011
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P. R. China%CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P. R. China
Research Department, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China
Sun Yat-sen University Cancer Center
Subjects
Dendritic Cells - immunology
Gene Transfer Techniques
Genes, Transgenic, Suicide
Genes, Tumor Suppressor
Genetic Therapy - methods
Genetic Vectors
Humans
Neoplasms - genetics
Neoplasms - therapy
Review
RNA Interference
RNA干扰
反义寡核苷酸
抗血管生成
树突状细胞
肿瘤基因治疗
肿瘤抑制基因
肿瘤治疗
非病毒载体
RNA interference
dendritic cells
angiogenesis
suicide gene
antisense RNA
viral vector
Gene therapy
tumor suppressor gene
oxidative stress
non-viral vector
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Summary:Gene therapy is one of the most attractive fields in tumor therapy. In past decades, significant progress has been achieved. Various approaches, such as viral and non-viral vectors and physical methods, have been developed to make gene delivery safer and more efficient. Several therapeutic strategies have evolved, including gene-based （tumor suppressor genes, suicide genes, antiangiogenic genes, cytokine and oxidative stress-based genes） and RNA-based （antisense oligonucleotides and RNA interference） approaches. In addition, immune response-based strategies （dendritic cell- and T cell-based therapy） are also under investigation in tumor gene therapy. This review highlights the progress and recent developments in gene delivery systems, therapeutic strategies, and possible clinical directions for gene therapy.
Bibliography:Q522
44-1195/R
Gene therapy, RNA interference, antisense RNA, tumor suppressor gene, suicide gene, oxidative stress, dendritic cells, angiogenesis, viral vector, non-viral vector
Q782
ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1000-467X
1944-446X
DOI:10.5732/cjc.010.10074