Pilot Study of Lamina Cribrosa Intensity Measurements in Glaucoma Using Swept-Source Optical Coherence Tomography

• Published in: Journal of glaucoma Vol. 26; no. 2; p. 138
• Main Authors: Srinivas, Sowmya, Dastiridou, Anna, Durbin, Mary K, Nittala, Muneeswar G, Huang, Alex A, Tan, James C H, Francis, Brian A, Sadda, Srinivas R, Chopra, Vikas
• Format: Journal Article
• Language: English
• Published: United States 01.02.2017
• Subjects: Adult; Aged; Female; Glaucoma, Open-Angle - pathology; Gonioscopy; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension - pathology; Optic Disk - pathology; Pilot Projects; Prospective Studies; Retinal Pigment Epithelium - pathology; Tomography, Optical Coherence - methods
• ISSN: 1536-481X
• DOI: 10.1097/IJG.0000000000000605

To compare the lamina cribrosa (LC) intensity in glaucoma-suspect eyes and eyes with mild to moderate glaucoma using swept-source optical coherence tomography. Optic disc volume scans were collected using swept-source optical coherence tomography in 19 clinically defined glaucoma-suspect eyes and 29 eyes with mild to moderate glaucoma. LC intensity was measured using Image J software, and the resultant values were normalized using the retinal pigment epithelium and vitreous signal. Mean age was 53.7±18.5 years in the glaucoma-suspect eyes and 63.0±16.1 years in the eyes with mild to moderate glaucoma (P=0.161). Significant differences in LC intensity were observed between the 2 groups, with median LC intensity values of 0.96 and 0.86 units in the glaucoma-suspect and the mild to moderate glaucoma groups, respectively (P<0.001). A weak positive correlation was found between mean deviation and normalized LC intensity (r=0.344; P=0.018). Intensity measurement of the LC is a potential novel parameter which warrants further study in the setting of glaucoma.